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Interaction between the bHLH-PAS protein Trachealess and the POU-domain protein Drifter, specifies tracheal cell fates
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Abstract
bHLH-PAS proteins represent a class of transcription factors involved in diverse biological
activities. Previous experiments demonstrated that the PAS domain confers target specificity
(Zelzer et al., 1997. Genes Dev. 11, 2079-2089). This suggested an association between
the PAS domain and additional DNA-binding proteins, which is essential for the induction
of specific target genes. A candidate for interaction with Trh is Drifter/Ventral
veinless, a POU-domain protein. A dual requirement for Trh and Drifter was identified
for the autoregulation of Trh and Drifter expression. Furthermore, ectopic expression
of both Trh and Dfr (but not each one alone) triggered trh autoregulation in several
embryonic tissues. A direct interaction between Drifter and Trh proteins, mediated
by the PAS domain of Trh and the POU domain of Drifter, was demonstrated.