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      Sarcoidosis

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          Abstract

          <p class="first" id="d4422995e136">Sarcoidosis is an inflammatory disorder of unknown cause that is characterized by granuloma formation in affected organs, most often in the lungs. Patients frequently suffer from cough, shortness of breath, chest pain and pronounced fatigue and are at risk of developing lung fibrosis or irreversible damage to other organs. The disease develops in genetically predisposed individuals with exposure to an as-yet unknown antigen. Genetic factors affect not only the risk of developing sarcoidosis but also the disease course, which is highly variable and difficult to predict. The typical T cell accumulation, local T cell immune response and granuloma formation in the lungs indicate that the inflammatory response in sarcoidosis is induced by specific antigens, possibly including self-antigens, which is consistent with an autoimmune involvement. Diagnosis can be challenging for clinicians because of the potential for almost any organ to be affected. As the aetiology of sarcoidosis is unknown, no specific treatment and no pathognomic markers exist. Thus, improved biomarkers to determine disease activity and to identify patients at risk of developing fibrosis are needed. Corticosteroids still constitute the first-line treatment, but new treatment strategies, including those targeting quality-of-life issues, are being evaluated and should yield appropriate, personalized and more effective treatments. </p>

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          Author and article information

          Journal
          Nature Reviews Disease Primers
          Nat Rev Dis Primers
          Springer Science and Business Media LLC
          2056-676X
          December 2019
          July 4 2019
          December 2019
          : 5
          : 1
          Article
          10.1038/s41572-019-0096-x
          31273209
          d38e6372-f486-480c-a8ca-7ae3e9c5befa
          © 2019

          http://www.springer.com/tdm

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