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      Mesangial Deposition of J Chain-Linked Polymeric IgA in IgA Nephropathy

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          Renal biopsy specimens from 8 patients with IgA nephropathy (Berger’s disease) were examined immunocytochemically at the light and electron microscopic levels with peroxidase-labeled antibodies to IgA, IgM, J chain and secretory component. In 2 of the 8 specimens heavy deposits of IgA, but no IgM, were found in the mesangium. After acid-urea treatment of these tissue sections, J chain, a subunit of polymeric immunoglobulins, was identified in a distribution similar to that of IgA. In the remaining 6 specimens, small amounts of IgM in addition to denser deposits of IgA and J chains were found. We conclude that the IgA deposits in at least some patients with Berger’s disease consist of IgA polymers linked by J chain.

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          Author and article information

          S. Karger AG
          03 December 2008
          : 33
          : 1
          : 61-64
          Cell Biology Research Laboratory, Department of Pathology, Department of Internal Medicine, Tokai University School of Medicine, Tokai; Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
          182907 Nephron 1983;33:61–64
          © 1983 S. Karger AG, Basel

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          Page count
          Pages: 4
          Original Paper

          Cardiovascular Medicine, Nephrology

          Immunocytochemistry, IgA nephropathy, J chain, IgA, Ultrastructure


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