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      Mesangial Deposition of J Chain-Linked Polymeric IgA in IgA Nephropathy

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          Abstract

          Renal biopsy specimens from 8 patients with IgA nephropathy (Berger’s disease) were examined immunocytochemically at the light and electron microscopic levels with peroxidase-labeled antibodies to IgA, IgM, J chain and secretory component. In 2 of the 8 specimens heavy deposits of IgA, but no IgM, were found in the mesangium. After acid-urea treatment of these tissue sections, J chain, a subunit of polymeric immunoglobulins, was identified in a distribution similar to that of IgA. In the remaining 6 specimens, small amounts of IgM in addition to denser deposits of IgA and J chains were found. We conclude that the IgA deposits in at least some patients with Berger’s disease consist of IgA polymers linked by J chain.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1983
          1983
          03 December 2008
          : 33
          : 1
          : 61-64
          Affiliations
          Cell Biology Research Laboratory, Department of Pathology, Department of Internal Medicine, Tokai University School of Medicine, Tokai; Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
          Article
          182907 Nephron 1983;33:61–64
          10.1159/000182907
          6403880
          d3a3e0f5-2aa2-4b53-8275-aca77bf81ed4
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 28 September 1982
          Page count
          Pages: 4
          Categories
          Original Paper

          Cardiovascular Medicine,Nephrology
          Ultrastructure,IgA nephropathy,J chain,IgA,Immunocytochemistry
          Cardiovascular Medicine, Nephrology
          Ultrastructure, IgA nephropathy, J chain, IgA, Immunocytochemistry

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