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      Resveratrol: A miraculous natural compound for diseases treatment

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          Abstract

          Resveratrol (3, 5, 4′‐trihydroxystilbene) is a nonflavonoid polyphenol that naturally occurs as phytoalexin. It is produced by plant sources such as grapes, apples, blueberries, plums, and peanut. This compound has critical roles in human health and is well known for its diverse biological activities such as antioxidant and anti‐inflammatory properties. Nowadays, due to rising incidence of different diseases such as cancer and diabetes, efforts to find novel and effective disease‐protective agents have led to the identification of plant‐derived compounds such as resveratrol. Furthermore, several in vitro and in vivo studies have revealed the effectiveness of resveratrol in various diseases such as diabetes mellitus, cardiovascular disease, metabolic syndrome, obesity, inflammatory, neurodegenerative, and age‐related diseases. This review presents an overview of currently available studies on preventive properties and essential molecular mechanisms involved in various diseases.

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          Bioavailability of resveratrol.

          Thomas Walle (2011)
          This paper reviews our current understanding of the absorption, bioavailability, and metabolism of resveratrol, with an emphasis on humans. The oral absorption of resveratrol in humans is about 75% and is thought to occur mainly by transepithelial diffusion. Extensive metabolism in the intestine and liver results in an oral bioavailability considerably less than 1%. Dose escalation and repeated dose administration of resveratrol does not appear to alter this significantly. Metabolic studies, both in plasma and in urine, have revealed major metabolites to be glucuronides and sulfates of resveratrol. However, reduced dihydroresveratrol conjugates, in addition to highly polar unknown products, may account for as much as 50% of an oral resveratrol dose. Although major sites of metabolism include the intestine and liver (as expected), colonic bacterial metabolism may be more important than previously thought. Deconjugation enzymes such as β-glucuronidase and sulfatase, as well as specific tissue accumulation of resveratrol, may enhance resveratrol efficacy at target sites. Resveratrol analogs, such as methylated derivatives with improved bioavailability, may be important in future research. © 2011 New York Academy of Sciences.
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            The worldwide environment of cardiovascular disease: prevalence, diagnosis, therapy, and policy issues: a report from the American College of Cardiology.

            Lawrence J. Laslett, Peter Alagona, Bernard A Clark … (2012)
            The environment in which the field of cardiology finds itself has been rapidly changing. This supplement, an expansion of a report created for the Board of Trustees, is intended to provide a timely snapshot of the socio-economic, political, and scientific aspects of this environment as it applies to practice both in the United States and internationally. This publication should assist healthcare professionals looking for the most recent statistics on cardiovascular disease and the risk factors that contribute to it, drug and device trends affecting the industry, and how the practice of cardiology is changing in the United States. Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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              Role of oxidized low density lipoprotein in atherogenesis.

              J Witztum, D. Steinberg (1991)
              Evidence to support an important role of oxidative modification in mediating the atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox-LDL or products of Ox-LDL can affect many components of the atherogenic process, including vasomotor properties and thrombosis, as well as lesion initiation and progression itself. These ideas suggest new approaches, that in combination with lowering of plasma cholesterol, could lead to the prevention of atherosclerosis and its complications.
              Article 0 comments Cited 232 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Mostafa Rezaei‐Tavirani:
                ORCID: http://orcid.org/0000-0003-1767-7475
                tavirany@yahoo.com
                Journal
                Journal ID (nlm-ta): Food Sci Nutr
                Journal ID (iso-abbrev): Food Sci Nutr
                Journal ID (doi): 10.1002/(ISSN)2048-7177
                Journal ID (publisher-id): FSN3
                Title: Food Science & Nutrition
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Electronic): 2048-7177
                Publication date (Electronic): 26 October 2018
                Publication date Collection: November 2018
                Volume: 6
                Issue: 8 ( doiID: 10.1002/fsn3.2018.6.issue-8 )
                Pages: 2473-2490
                Affiliations
                [ 1 ] Department of Biochemistry Faculty of Medicine Tehran University of Medical Sciences Tehran Iran
                [ 2 ] Student Research Committee Proteomics Research Center Shahid Beheshti University of Medical Sciences Tehran Iran
                [ 3 ] Proteomics Research Center Faculty of Paramedical Sciences Shahid Beheshti University of Medical Sciences Tehran Iran
                [ 4 ] Hearing Disorders Research Center Shahid Beheshti University of Medical Sciences Tehran Iran
                Author notes
                [*] [* ] Correspondence

                Mostafa Rezaei‐Tavirani, Paramedical Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

                Email: tavirany@ 123456yahoo.com

                [†]

                Contributed equally in this work as the first author.

                Author information
                http://orcid.org/0000-0003-1767-7475
                Article
                Publisher ID: FSN3855
                DOI: 10.1002/fsn3.855
                PMC ID: 6261232
                PubMed ID: 30510749
                SO-VID: d3b180b5-ac02-4f06-b6f6-328558356cd3
                Copyright © © 2018 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc.
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 17 November 2017
                Date revision received : 24 September 2018
                Date accepted : 26 September 2018
                Page count
                Figures: 9, Tables: 2, Pages: 18, Words: 14349
                Funding
                Funded by: Proteomics Research Center, Shahid Beheshti University of Medical Science
                Categories
                Subject: Review
                Subject: Review
                Custom metadata
                source-schema-version-number 2.0
                component-id fsn3855
                cover-date November 2018
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_NLMPMC version:version=5.5.3 mode:remove_FC converted:28.11.2018

                Keywords: antioxidant,dietary,natural compound,polyphenol,resveratrol
                Data availability:
                Keywords: antioxidant, dietary, natural compound, polyphenol, resveratrol

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