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      Tissue regeneration as next-generation therapy for COPD – potential applications

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          Abstract

          COPD is a major cause of chronic morbidity and mortality worldwide, and there is a need to develop more effective therapeutic strategies to replace specialized treatment such as lung transplantation. Recent studies suggest that recognition of apoptotic lung epithelial or endothelial cells may result in growth factors to stimulate cell replacement, and defects in these processes may contribute to the pathogenesis of COPD. Furthermore, recent animal and human studies have revealed that tissue-specific stem cells and bone marrow-derived cells contribute to lung tissue regeneration and protection, and thus administration of exogenous stem/progenitor cells or humoral factors responsible for activation of endogenous stem/progenitor cells may be a potent next-generation therapy for COPD.

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          Author and article information

          Journal
          Int J Chron Obstruct Pulmon Dis
          International Journal of COPD
          International Journal of Chronic Obstructive Pulmonary Disease
          Dove Medical Press
          1176-9106
          1178-2005
          December 2008
          December 2008
          : 3
          : 4
          : 509-514
          Affiliations
          Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
          Author notes
          Correspondence: Shunsuke Ohnishi, Fujishirodai 5-7-1, Suita, Osaka, 565-8565, Japan, Tel +6 6833 5012, Fax +6 6833 9865, Email shunpou@ 123456hotmail.com
          Article
          copd-3-509
          2650613
          19281069
          © 2008 Dove Medical Press Limited. All rights reserved
          Categories
          Reviews

          Respiratory medicine

          growth factor, stem cell, cell therapy, copd, regenerative medicine, bone marrow

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