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      Quantitative Ultrastructural Measurement of Innervation Density, Neurotransmitter Vesicles and Neuromuscular Cleft Width in the Rabbit Central Ear Artery and Its Main Side Branch

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          Abstract

          The purpose of this study was to provide anatomical information about innervation density and the neuromuscular relationship in the rabbit central ear artery and its main side branch, so that, when combined with functional observations, a better understanding of neuroeffector mechanisms in these vessels could be established. Electron-microscopic methods were used to measure number and size of axon varicosities, their content of vesicles, the sizes of dense cores in the small vesicles and the neuromuscular cleft width. For each 100 µm of the outer circumference of the tunica media, the central ear artery contained 4 varicosities with a total cross-sectional area of 2.2 µm<sup>2</sup>, and the main side branch about 9 varicosities with a total cross-sectional area of 4.1 µm<sup>2</sup>. On the average, the varicosities of the central and branch arteries contained 93.6 and 95.1 small, and 2.3 and 1.9 large vesicles, respectively, per micron. The diameter of dense cores in the small vesicles was significantly smaller in the main side branch (18.3 vs. 16.7 nm). In the central ear artery, the mean cleft width was 5.27 µm, and 3% of all clefts were narrower than 1 µm. In the main side branch, the mean cleft width was 2.77 µm, and 22% were narrower than 1 µm. Thus, the innervation of the main side branch is closer to the vascular smooth muscle cells and is characterized by a larger number of smaller varicosities per unit circumference. Although vesicle density is the same as in the central artery, the dense cores are smaller in diameter. These data do not provide an explanation as to why the response of the main side branch to nerve stimulation in vitro is proportionally weaker. The reasons for this apparent contradiction are not clear, but we offer some possible explanations.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1987
          1987
          23 September 2008
          : 24
          : 4
          : 181-191
          Affiliations
          aDepartment of Pathology, Stanford University School of Medicine, Stanford, Calif.; bDepartment of Pharmacology, University of Vermont College of Medicine, Burlington, Vt., USA
          Article
          158694 Blood Vessels 1987;24:181–191
          10.1159/000158694
          © 1987 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 11
          Categories
          Research Paper

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