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      Oral human papillomavirus prevalence and type distribution by country (Brazil, Mexico and the United States) and age among HPV infection in men study participants

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          Abstract

          Incidence of human papillomavirus (HPV) attributable oropharyngeal cancers (OPCs) has been increasing globally, especially among men in high-income countries. There is a lack of studies comparing oral HPV prevalence by age and country among healthy men. The purpose of our study was to assess oral HPV prevalence by country and age. Participants of the HPV Infection in Men Study (HIM), a cohort of 3,098 healthy men from São Paulo, Brazil, Cuernavaca, Mexico and Tampa, USA, were studied. Oral HPV prevalence and type distribution were assessed using the SPF 10 PCR-DEIA-LiPA 25 system. The prevalence of any HPV in Brazil, Mexico and the US was 8.7% (95% CI: 7.1%, 10.4%), 10.0% (95% CI: 8.3%, 12.1%) and 7.6% (95% CI: 5.9%, 9.5%), respectively, while the prevalence of high-risk HPV was 5.3% (95% CI: 4.1%, 6.7%), 7.3% (95% CI: 5.7%, 9.0%) and 5.4% (95% CI: 4.0%, 7.0%), respectively. No significant differences in prevalence of grouped HPV types were observed by country despite significant differences in sexual behaviors. However, the age-specific prevalence of oral HPV differed by country. Brazilian (6.0% [95% CI: 3.4%, 9.7%]) and Mexican (9.2% [95% CI: 5.6%, 14.0%]) participants had peak high-risk HPV prevalence among men aged 41–50 years whereas the US participants had peak prevalence at ages 31–40 years (11.0% [95% CI: 6.4%, 17.3%]). In conclusion, oral HPV prevalence was low with no difference in overall prevalence observed by country. Factors associated with the differences in oral HPV age-patterning by country and sexual orientation require further study.

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          Author and article information

          Journal
          0042124
          4284
          Int J Cancer
          Int. J. Cancer
          International journal of cancer
          0020-7136
          1097-0215
          24 November 2019
          01 November 2019
          01 June 2020
          01 June 2020
          : 146
          : 11
          : 3026-3033
          Affiliations
          [1 ]Center for Immunization and Infection Research in Cancer (CIIRC), H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
          [2 ]School of Medicine, University of São Paulo, São Paulo, Brazil
          [3 ]Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
          [4 ]Mexican Institute of Social Security, Mexico City, Mexico
          [5 ]H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
          Author notes
          Correspondence to: Dr Anna R. Giuliano, anna.giuliano@ 123456moffitt.org
          Article
          PMC7117984 PMC7117984 7117984 nihpa1060759
          10.1002/ijc.32713
          7117984
          31583681
          Categories
          Article

          Mexico, oral HPV, HIM study, Brazil, USA

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