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      Extracellular matrix remodelling: the role of matrix metalloproteinases.

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      The Journal of pathology
      Wiley

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          Abstract

          Matrix metalloproteinases (MMPs) are a growing family of metalloendopeptidases that cleave the protein components of the extracellular matrix and thereby play a central role in tissue remodelling. For many years following their discovery, MMPs were believed to function primarily as regulators of ECM composition and to facilitate cell migration simply by removing barriers such as collagen. It is becoming increasingly clear, however, that MMPs are implicated in the functional regulation of a host of non-ECM molecules that include growth factors and their receptors, cytokines and chemokines, adhesion receptors and cell surface proteoglycans, and a variety of enzymes. MMPs therefore play an important role in the control of cellular interactions with and response to their environment in conditions that promote tissue turnover, be they physiological, such as normal development, or pathological, such as inflammation and cancer. This review summarizes some of the recent discoveries that have shed new light on the role of MMPs in physiology and disease.

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          Author and article information

          Journal
          J Pathol
          The Journal of pathology
          Wiley
          0022-3417
          0022-3417
          Jul 2003
          : 200
          : 4
          Affiliations
          [1 ] Experimental Pathology Division, Institut Universitaire de Pathologie, Université de Lausanne, 25 Rue du Bagnon, CH-1011 Lausanne, Switzerland.
          Article
          10.1002/path.1400
          12845612
          d3e0e0cc-4662-45af-98fd-4d939e9c7d15
          Copyright 2003 John Wiley & Sons, Ltd.
          History

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