24
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Extracellular matrix remodelling: the role of matrix metalloproteinases.

      The Journal of Pathology

      Bone Development, physiology, Cadherins, metabolism, Cytokines, Enzyme Activation, Enzyme Inhibitors, therapeutic use, Extracellular Matrix, enzymology, pathology, Growth Substances, Humans, Matrix Metalloproteinase Inhibitors, Matrix Metalloproteinases, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, drug therapy, Wound Healing

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Matrix metalloproteinases (MMPs) are a growing family of metalloendopeptidases that cleave the protein components of the extracellular matrix and thereby play a central role in tissue remodelling. For many years following their discovery, MMPs were believed to function primarily as regulators of ECM composition and to facilitate cell migration simply by removing barriers such as collagen. It is becoming increasingly clear, however, that MMPs are implicated in the functional regulation of a host of non-ECM molecules that include growth factors and their receptors, cytokines and chemokines, adhesion receptors and cell surface proteoglycans, and a variety of enzymes. MMPs therefore play an important role in the control of cellular interactions with and response to their environment in conditions that promote tissue turnover, be they physiological, such as normal development, or pathological, such as inflammation and cancer. This review summarizes some of the recent discoveries that have shed new light on the role of MMPs in physiology and disease. Copyright 2003 John Wiley & Sons, Ltd.

          Related collections

          Author and article information

          Journal
          12845612
          10.1002/path.1400

          Comments

          Comment on this article