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      Renal Pathology of Fetuses with Congenital Nephrotic Syndrome of the Finnish Type

      ,

      Nephron

      S. Karger AG

      Congenital nephrotic syndrome, Fetal, Kidney, Morphometric, Pathology

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          Abstract

          A light microscopic study was performed on 10 fetal kidneys of congenital nephrosis of the Finnish type (CNF) and compared to 22 controls. The gestational age of the fetuses ranged from 16 to 24 weeks. A quantitative morphometric analysis was carried out on 6 CNF fetuses and 6 age-matched controls. The organogenesis of the kidney and the nephronogenesis proceeded normally in CNF. The size and the number of glomeruli were the same in CNF and controls. An increase in the proportion of mature glomeruli and a decrease in the percentage of visceral epithelial cells in them suggested accelerated glomerular maturation in CNF. Focal mesangial cell hyperplasia and dilatation of glomerular capillaries with congestion of blood were more often obvious in CNF than in controls. Marked dilatation of proximal tubular lumens and Bowman’s spaces were typical of CNF.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1981
          1981
          03 December 2008
          : 29
          : 3-4
          : 158-163
          Affiliations
          Department of Pathology, University of Oulu, Oulu, Finland; Children’s Hospital, University of Helsinki, Finland
          Article
          182343 Nephron 1981;29:158–163
          10.1159/000182343
          7329491
          © 1981 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Pathology, Morphometric, Kidney, Fetal, Congenital nephrotic syndrome

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