+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Renal Pathology of Fetuses with Congenital Nephrotic Syndrome of the Finnish Type



      S. Karger AG

      Congenital nephrotic syndrome, Fetal, Kidney, Morphometric, Pathology

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          A light microscopic study was performed on 10 fetal kidneys of congenital nephrosis of the Finnish type (CNF) and compared to 22 controls. The gestational age of the fetuses ranged from 16 to 24 weeks. A quantitative morphometric analysis was carried out on 6 CNF fetuses and 6 age-matched controls. The organogenesis of the kidney and the nephronogenesis proceeded normally in CNF. The size and the number of glomeruli were the same in CNF and controls. An increase in the proportion of mature glomeruli and a decrease in the percentage of visceral epithelial cells in them suggested accelerated glomerular maturation in CNF. Focal mesangial cell hyperplasia and dilatation of glomerular capillaries with congestion of blood were more often obvious in CNF than in controls. Marked dilatation of proximal tubular lumens and Bowman’s spaces were typical of CNF.

          Related collections

          Author and article information

          S. Karger AG
          03 December 2008
          : 29
          : 3-4
          : 158-163
          Department of Pathology, University of Oulu, Oulu, Finland; Children’s Hospital, University of Helsinki, Finland
          182343 Nephron 1981;29:158–163
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Original Paper

          Cardiovascular Medicine, Nephrology

          Pathology, Morphometric, Kidney, Fetal, Congenital nephrotic syndrome


          Comment on this article