Omni-tomography: Next-generation Biomedical Imaging

Abstract

Omni-tomography is enabled by interior tomography that has been developed over the past five years. By omni-tomography, we envision that the next stage of biomedical imaging will be the grand fusion of many tomographic modalities into a single gantry (all in one) for simultaneous data acquisition of numerous complementary features (all at once). This integration has great synergistic potential for development of systems biology, personalized and preventive medicine, because many physiological processes are dynamic and complicated, and must be observed promptly, comprehensively, sensitively, specifically, and non-invasively. In this perspective, we first present the background for and power of omni-tomography, then discuss its important applications in vulnerable plaque characterization and intratumor heterogeneity evaluation, review its enabling theory and technology, explain for the first time the feasibility of the CT-MRI scanner as an example, and finally suggest exciting research opportunities.