Ashley Budu-Aggrey:
ORCID: http://orcid.org/0000-0002-8911-2492
Role: Data curationRole: Formal analysisRole: InvestigationRole: Writing – original
draftRole: Writing – review & editing
Ben Brumpton: Role: Data curationRole: Formal analysisRole: Writing – original draftRole: Writing
– review & editing
Jess Tyrrell:
ORCID: http://orcid.org/0000-0002-9256-6065
Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Sarah Watkins:
ORCID: http://orcid.org/0000-0002-8034-8095
Role: Data curationRole: Formal analysisRole: InvestigationRole: Writing – original
draftRole: Writing – review & editing
Ellen H. Modalsli:
ORCID: http://orcid.org/0000-0002-3061-1844
Role: Formal analysisRole: Writing – review & editing
Carlos Celis-Morales:
ORCID: http://orcid.org/0000-0003-2612-3917
Role: InvestigationRole: Writing – review & editing
Lyn D. Ferguson:
ORCID: http://orcid.org/0000-0002-6136-8349
Role: InvestigationRole: Writing – original draftRole: Writing – review & editing
Gunnhild Åberge Vie:
ORCID: http://orcid.org/0000-0003-1552-5291
Role: InvestigationRole: Writing – review & editing
Tom Palmer:
ORCID: http://orcid.org/0000-0003-4655-4511
Role: Formal analysisRole: MethodologyRole: Writing – review & editing
Lars G. Fritsche:
ORCID: http://orcid.org/0000-0002-2110-1690
Role: Data curationRole: Writing – review & editing
Mari Løset: Role: Data curationRole: Writing – review & editing
Jonas Bille Nielsen:
ORCID: http://orcid.org/0000-0002-6654-2852
Role: Data curationRole: Writing – review & editing
Wei Zhou:
ORCID: http://orcid.org/0000-0001-7719-0859
Role: Data curationRole: Writing – review & editing
Lam C. Tsoi:
ORCID: http://orcid.org/0000-0003-1627-5722
Role: Data curationRole: Writing – review & editing
Andrew R. Wood: Role: Data curationRole: Writing – review & editing
Samuel E. Jones:
ORCID: http://orcid.org/0000-0003-0153-922X
Role: Data curationRole: Writing – review & editing
Robin Beaumont:
ORCID: http://orcid.org/0000-0003-0750-8248
Role: Data curationRole: Writing – review & editing
Marit Saunes: Role: InvestigationRole: Writing – review & editing
Pål Richard Romundstad:
ORCID: http://orcid.org/0000-0003-2061-4336
Role: Data curationRole: Writing – review & editing
Stefan Siebert:
ORCID: http://orcid.org/0000-0002-1802-7311
Role: InvestigationRole: Writing – review & editing
Iain B. McInnes: Role: InvestigationRole: Writing – review & editing
James T. Elder:
ORCID: http://orcid.org/0000-0003-4215-3294
Role: Data curationRole: Writing – review & editing
George Davey Smith:
ORCID: http://orcid.org/0000-0002-1407-8314
Role: MethodologyRole: Writing – review & editing
Timothy M. Frayling:
ORCID: http://orcid.org/0000-0001-8362-2603
Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Bjørn Olav Åsvold:
ORCID: http://orcid.org/0000-0003-3837-2101
Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Sara J. Brown:
ORCID: http://orcid.org/0000-0002-3232-5251
Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Naveed Sattar: Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Lavinia Paternoster:
ORCID: http://orcid.org/0000-0003-2514-0889
Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Cathryn Lewis: Role: Academic Editor
Journal ID (nlm-ta): PLoS Med
Journal ID (iso-abbrev): PLoS Med
Journal ID (publisher-id): plos
Journal ID (pmc): plosmed
Title:
PLoS Medicine
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1549-1277
ISSN
(Electronic):
1549-1676
Publication date
(Electronic):
31
January
2019
Publication date Collection:
January
2019
Volume: 16
Issue: 1
Electronic Location Identifier: e1002739
Affiliations
[1
]
Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol,
Bristol, United Kingdom
[2
]
Bristol Medical School, Population Health Sciences, University of Bristol, Bristol,
United Kingdom
[3
]
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing,
NTNU, Norwegian University of Science and Technology, Trondheim, Norway
[4
]
Department of Thoracic Medicine, St. Olavs Hospital, Trondheim University Hospital,
Trondheim, Norway
[5
]
Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University
of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, United Kingdom
[6
]
European Centre for Environment and Human Health, University of Exeter Medical School,
The Knowledge Spa, Truro, United Kingdom
[7
]
Department of Public Health and Nursing, NTNU, Norwegian University of Science and
Technology, Trondheim, Norway
[8
]
Department of Dermatology, St. Olav’s Hospital, Trondheim University Hospital, Trondheim,
Norway
[9
]
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow,
United Kingdom
[10
]
Department of Mathematics and Statistics, Lancaster University, Lancaster, United
Kingdom
[11
]
Department of Internal Medicine, Division of Cardiology, University of Michigan Medical
School, Ann Arbor, Michigan, United States of America
[12
]
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann
Arbor, Michigan, United States of America
[13
]
Department of Dermatology, University of Michigan, Ann Arbor, Michigan, United States
of America
[14
]
Department of Biostatistics, Center for Statistical Genetics, University of Michigan,
Ann Arbor, Michigan, United States of America
[15
]
Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science
and Technology, Trondheim, Norway
[16
]
Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow,
United Kingdom
[17
]
Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, United States of America
[18
]
Department of Endocrinology, St. Olav’s Hospital, Trondheim University Hospital, Trondheim,
Norway
[19
]
Skin Research Group, School of Medicine, University of Dundee, Dundee, United Kingdom
[20
]
Department of Dermatology, Ninewells Hospital and Medical School, Dundee, United Kingdom
King’s College London, UNITED KINGDOM
Author notes
I have read the journal’s policy and the authors of this manuscript have the following
competing interests: IBM has received grants from Arthritis Research UK during the
conduct of the study; grants and personal fees from Novartis, grants and personal
fees from Janssen, grants and personal fees from Celgene, grants and personal fees
from Abbvie, grants from BI, grants and personal fees from UCB, personal fees from
Lilly, grants and personal fees from BMS. LP has received personal fees from Merck
for Scientific Input Engagement related to MR methodology. SS has received grants
from Arthritis Research UK during the conduct of the study; research grants from Janssen,
BMS, Celgene, UCB, Boehringer Ingelheim and consultancy/speaker’s fees from AbbVie,
UCB, Celgene, Pfizer, Janssen, Boehringer Ingelheim, and Novartis. SJB has received
honoraria for invited lectures at the British Association of Dermatologists’ annual
meetings and the AAAAI annual meetings. GDS is a member of the Editorial Board of
PLOS Medicine.
‡These authors are joint last authors on this work.
Author information
Article
Publisher ID:
PMEDICINE-D-18-02371
DOI: 10.1371/journal.pmed.1002739
PMC ID: 6354959
PubMed ID: 30703100
SO-VID: d41c81c5-daf4-44a9-a510-b7b96dddd027
Copyright © © 2019 Budu-Aggrey et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: British Heart Foundation
Award ID: RE/13/5/30177
Award Recipient
:
ORCID: http://orcid.org/0000-0002-8911-2492
Ashley Budu-Aggrey
Funded by: British Skin Foundation (GB)
Award ID: 8010 Innovative Project
Award Recipient
:
ORCID: http://orcid.org/0000-0003-2514-0889
Lavinia Paternoster
Funded by: UK Medical Research Council
Award ID: MC_UU_00011/1
Award Recipient
:
ORCID: http://orcid.org/0000-0002-1407-8314
George Davey Smith
Funded by: European Regional Development Fund (ERDF)
Award Recipient
:
ORCID: http://orcid.org/0000-0002-9256-6065
Jess Tyrrell
Funded by: funder-id http://dx.doi.org/10.13039/501100000273, Diabetes Research & Wellness Foundation;
Award Recipient
:
ORCID: http://orcid.org/0000-0002-9256-6065
Jess Tyrrell
Funded by: funder-id http://dx.doi.org/10.13039/100004440, Wellcome Trust;
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0750-8248
Robin Beaumont
Funded by: Royal Society
Award ID: 104150/Z/14/Z
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0750-8248
Robin Beaumont
Funded by: UK Medical Research Council
Award ID: MR/M005070/1
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0153-922X
Samuel E. Jones
Funded by: European Research Council
Award ID: 323195:GLUCOSEGENES-FP7-IDEAS-ERC
Award Recipient
:
ORCID: http://orcid.org/0000-0001-8362-2603
Timothy M. Frayling
Funded by: Stiftelsen Kristian Gerhard Jebsen; Faculty of Medicine and Health Sciences, NTNU
Award Recipient
:
ORCID: http://orcid.org/0000-0003-3837-2101
Bjørn Olav Åsvold
Funded by: The Liaison Committee for education, research and innovation in Central Norway
Award Recipient
:
ORCID: http://orcid.org/0000-0003-3837-2101
Bjørn Olav Åsvold
Funded by: the Joint Research Committee between St. Olavs hospital and the Faculty of Medicine
and Health Sciences, NTNU
Award Recipient
:
ORCID: http://orcid.org/0000-0003-3837-2101
Bjørn Olav Åsvold
Funded by: Norwegian Research Council
Award ID: 250335
Award Recipient
:
ORCID: http://orcid.org/0000-0003-1552-5291
Gunnhild Åberge Vie
Funded by: Danish Heart Foundation
Award Recipient
:
ORCID: http://orcid.org/0000-0002-6654-2852
Jonas Bille Nielsen
Funded by: funder-id http://dx.doi.org/10.13039/100004440, Wellcome Trust;
Award ID: 106865/Z/15/Z
Award Recipient
:
ORCID: http://orcid.org/0000-0002-3232-5251
Sara J. Brown
Funded by: British Heart Foundation
Award ID: RE/13/5/30177
Award Recipient
:
ORCID: http://orcid.org/0000-0002-6136-8349
Lyn D. Ferguson
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award Recipient
:
ORCID: http://orcid.org/0000-0003-4215-3294
James T. Elder
Funded by: University of Michigan
Funded by: The Research Council of Norway
AB-A and LP are funded by a grant awarded by the British Skin Foundation (8010 Innovative
Project) (
http://www.britishskinfoundation.org.uk/). AB-A, LP, SW, and GDS work in a research unit funded by the UK Medical Research
Council (MC_UU_00011/1) (
https://mrc.ukri.org/). JT is funded by the European Regional Development Fund (ERDF) (
http://ec.europa.eu/regional_policy/en/funding/erdf/) and a Diabetes Research and Wellness Foundation fellowship (
https://www.drwf.org.uk/). RNB is funded by the Wellcome Trust (
https://wellcome.ac.uk/) and Royal Society grant 104150/Z/14/Z (
https://royalsociety.org). SEJ is funded by the Medical Research Council (grant MR/M005070/1) (
https://mrc.ukri.org/). JT, RNB, and SEJ’s analysis of UK Biobank was under project 9072. TMF and ARW are
supported by the European Research Council (grant 323195:GLUCOSEGENES-FP7-IDEAS-ERC)
(
https://erc.europa.eu/). BB, ML, LGF, and BOA work in a research unit funded by Stiftelsen Kristian Gerhard
Jebsen; Faculty of Medicine and Health Sciences, NTNU (
https://stiftkgj.no/what-we-do/k-g-jebsen-centres-of-medical-research/?lang=en); The Liaison Committee for education, research and innovation in Central Norway
(
https://helsemidt.no/helsefaglig/helsefaglig/samarbeidsorganet); and the Joint Research Committee between St. Olav’s Hospital and the Faculty of
Medicine and Health Sciences, NTNU (
https://www.ntnu.edu/). EHM and ML were supported by a research grant from the Liaison Committee for education,
research and innovation in Central Norway (
https://helsemidt.no/helsefaglig/helsefaglig/samarbeidsorganet). GAV is supported by a research grant from the Norwegian Research Council, grant
number 250335 (
https://www.forskningsradet.no/en/Home_page/1177315753906). JBN was supported by grants from the Danish Heart Foundation (
https://hjerteforeningen.dk/english/) and the Lundbeck Foundation (
https://www.lundbeckfonden.com/en/). SJB holds a Wellcome Trust Senior Research Fellowship in Clinical Science (106865/Z/15/Z)
(
https://wellcome.ac.uk/). LDF is funded by the British Heart Foundation (BHF) Research Excellence award,
grant number RE/13/5/30177 (
https://www.bhf.org.uk/for-professionals/information-for-researchers/what-we-fund). The genotyping in HUNT was financed by the National Institutes of Health (NIH)
(
https://www.nih.gov/); the University of Michigan (
https://www.umich.edu/); The Research Council of Norway (
https://www.forskningsradet.no/en/Home_page/1177315753906); The Liaison Committee for education, research and innovation in Central Norway
(
https://helsemidt.no/helsefaglig/helsefaglig/samarbeidsorganet); and the Joint Research Committee between St. Olav’s hospital and the Faculty of
Medicine and Health Sciences, NTNU (
https://www.ntnu.edu/). The psoriasis meta-GWAS was funded by multiple sources, including the NIH (
https://www.nih.gov/). The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Clinical Medicine
Subject:
Clinical Immunology
Subject:
Autoimmune Diseases
Subject:
Psoriasis
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Clinical Immunology
Subject:
Autoimmune Diseases
Subject:
Psoriasis
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Clinical Immunology
Subject:
Autoimmune Diseases
Subject:
Psoriasis
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Body Mass Index
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Body Mass Index
Subject:
Research and Analysis Methods
Subject:
Mathematical and Statistical Techniques
Subject:
Statistical Methods
Subject:
Metaanalysis
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Statistics
Subject:
Statistical Methods
Subject:
Metaanalysis
Subject:
Biology and Life Sciences
Subject:
Computational Biology
Subject:
Genome Analysis
Subject:
Genome-Wide Association Studies
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genomics
Subject:
Genome Analysis
Subject:
Genome-Wide Association Studies
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Human Genetics
Subject:
Genome-Wide Association Studies
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Obesity
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Obesity
Subject:
Biology and Life Sciences
Subject:
Nutrition
Subject:
Diet
Subject:
Alcohol Consumption
Subject:
Medicine and Health Sciences
Subject:
Nutrition
Subject:
Diet
Subject:
Alcohol Consumption
Subject:
Medicine and Health Sciences
Subject:
Dermatology
Subject:
Skin Diseases
Subject:
Research and Analysis Methods
Subject:
Mathematical and Statistical Techniques
Subject:
Statistical Methods
Subject:
Instrumental Variable Analysis
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Statistics
Subject:
Statistical Methods
Subject:
Instrumental Variable Analysis
