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      Assessing interethnic admixture using an X-linked insertion-deletion multiplex.

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          Abstract

          In this study, a PCR multiplex was optimized, allowing the simultaneous analysis of 13 X-chromosome Insertion/deletion polymorphisms (INDELs). Genetic variation observed in Africans, Europeans, and Native Americans reveals high inter-population variability. The estimated proportions of X-chromosomes in an admixed population from the Brazilian Amazon region show a predominant Amerindian contribution (approximately 41%), followed by European (approximately 32%) and African (approximately 27%) contributions. The proportion of Amerindian contribution based on X-linked data is similar to the expected value based on mtDNA and Y-chromosome information. The accuracy for assessing interethnic admixture, and the high differentiation between African, European, and Native American populations, demonstrates the suitability of this INDEL set to measure ancestry proportions in three-hybrid populations, as it is the case of Latin American populations.

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          Author and article information

          Journal
          Am. J. Hum. Biol.
          American journal of human biology : the official journal of the Human Biology Council
          Wiley-Blackwell
          1520-6300
          1042-0533
          June 18 2009
          : 21
          : 5
          Affiliations
          [1 ] Laboratório de Genética Humana e Médica, Departamento de Patologia, Universidade Federal do Pará, CEP: 66075-970 Belém, Pará, Brazil.
          Article
          10.1002/ajhb.20950
          19533621
          d41e1d80-8f44-44ae-ada8-47ff2bee1215
          History

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