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      Random versus directionally persistent cell migration.

      Nature reviews. Molecular cell biology

      Protein Transport, Animals, Cell Movement, Cell Polarity, Cell Surface Extensions, metabolism, Extracellular Matrix, Humans

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          Abstract

          Directional migration is an important component of cell motility. Although the basic mechanisms of random cell movement are well characterized, no single model explains the complex regulation of directional migration. Multiple factors operate at each step of cell migration to stabilize lamellipodia and maintain directional migration. Factors such as the topography of the extracellular matrix, the cellular polarity machinery, receptor signalling, integrin trafficking, integrin co-receptors and actomyosin contraction converge on regulation of the Rho family of GTPases and the control of lamellipodial protrusions to promote directional migration.

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          Author and article information

          Journal
          19603038
          2752299
          10.1038/nrm2729

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