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      Strengthened connections between engrams encode specific memories

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          Abstract

          In previous studies, memory storage was localized to engram cells distributed across the brain. While these studies have provided an individual cellular profile of engram cells, their synaptic connectivity, or whether they follow Hebbian mechanisms, remains uncertain. Therefore, our recent study investigated whether synapses between engram cells exhibit selectively enhanced structural and functional properties following memory formation. This was accomplished using a newly developed technique called “dual-eGRASP”. We found that the number and size of spines on CA1 engram cells that receive inputs from CA3 engram cells were larger than at other synapses. We further observed that this enhanced connectivity correlated with induced memory strength. CA3 engram synapses exhibited increased release probability, while CA1 engram synapses produced enhanced postsynaptic responses. CA3 engram to CA1 engram projections showed strong occlusion of long-term potentiation. We demonstrated that the synaptic connectivity of CA3 to CA1 engram cells was strengthened following memory formation. Our results suggest that Hebbian plasticity occurs during memory formation among engram cells at the synapse level.

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          Author and article information

          Journal
          BMB Rep
          BMB Rep
          BMB Reports
          Korean Society for Biochemistry and Molecular Biology
          1976-6696
          1976-670X
          August 2018
          31 August 2018
          : 51
          : 8
          : 369-370
          Affiliations
          School of Biological Sciences, Seoul National University, Seoul 08826, Korea
          Author notes
          [* ]Corresponding author. E-mail: kaang@ 123456snu.ac.kr
          Article
          bmb-51-369
          10.5483/BMBRep.2018.51.8.176
          6130830
          30078390
          d42a9d5e-9ef7-4362-9001-10d53b340bcc
          Copyright © 2018 by the The Korean Society for Biochemistry and Molecular Biology

          This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

          History
          : 07 July 2018
          Categories
          Perspective

          dendritic spine,dual-egrasp,hippocampus,memory engram,synaptic plasticity

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