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      Copper and carcinogenesis

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      Critical Reviews in Oncology/Hematology

      Elsevier BV

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          Abstract

          Metal ions play an important role in biological systems, and without their catalytic presence in trace or ultratrace amounts many essential co-factors for many biochemical reactions would not take place. However, they become toxic to cells when their concentrations surpass certain optimal (natural) levels. Copper is an essential metal. Catalytic copper, because of its mobilization and redox activity, is believed to play a central role in the formation of reactive oxygen species (ROS), such as O2-* and *OH radicals, that bind very fast to DNA, and produce damage by breaking the DNA strands or modifying the bases and/or deoxyribose leading to carcinogenesis. The chemistry and biochemistry of copper is briefly accounted together with its involvement in cancer and other diseases.

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          Author and article information

          Journal
          Critical Reviews in Oncology/Hematology
          Critical Reviews in Oncology/Hematology
          Elsevier BV
          10408428
          April 2002
          April 2002
          : 42
          : 1
          : 57-64
          Article
          11923068
          © 2002

          https://www.elsevier.com/tdm/userlicense/1.0/

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