We have investigated the impact of titanium dioxide nanoparticles on the ionic contamination of liquid crystals. Nematic liquid crystals with high and low initial ionic contamination have been examined. It has been shown that titanium dioxide nanoparticles reduced the ion density of liquid crystals with high initial ionic contamination from 134.5 × 10 12 cm −3 to 63.2 × 10 12 cm −3. In the case of liquid crystals with low initial ionic contamination, the nanoparticles led to an insignificant increase of ion density from 19.8 × 10 12 cm −3 to 25.7 × 10 12 cm −3.