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      Biochemistry and molecular cell biology of diabetic complications.

      Nature

      metabolism, Protein Kinase C, pathology, complications, Hyperglycemia, Humans, Hexosamines, Glycosylation End Products, Advanced, Forecasting, etiology, Diabetic Angiopathies, Diabetes Mellitus, Diabetes Complications

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          Abstract

          Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.

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          Journal
          10.1038/414813a
          11742414

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