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      Curcumin-loading potentiates the chemotherapeutic efficacy of selenium nanoparticles in HCT116 cells and Ehrlich's ascites carcinoma bearing mice.

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          Abstract

          The anticancer properties of selenium (Se) and curcumin nanoparticles in solo formulations as well as in combination with other therapeutic agents have been proved time and again. Exploiting this facet of the two, we clubbed their tumoricidal characteristics and designed curcumin loaded Se nanoparticles (Se-CurNPs) to achieve an enhanced therapeutic effect. We evaluated their therapeutic effects on different cancer cell lines and Ehrlich's ascites carcinoma mouse model. In vitro results showed that Se-CurNPs were most effective on colorectal carcinoma cells (HCT116) compared to the other cancer cell lines used and possessed pleiotropic anticancer effects. The therapeutic effect on HCT116 was primarily attributed to an elevated level of autophagy and apoptosis as evident from significant up-regulation of autophagy associated (LC3B-II) and pro-apoptotic (Bax) proteins, down-regulation of anti-apoptotic (Bcl-2) protein and Cytochrome c (cyt c) release from mitochondria along with reduced NFκB signaling and EMT based machineries marked by downregulation of inflammation (NFκB, phospho-NFκB) and epithelial-mesenchymal transition (CD44, N-cadherin) associated proteins. In vivo studies on Ehrlich's ascites carcinoma (EAC) mice model indicated that Se-CurNPs significantly reduced the tumor load and enhanced the mean survival time (days) of tumor-bearing EAC mice.

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          Author and article information

          Journal
          Eur J Pharm Biopharm
          European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
          Elsevier BV
          1873-3441
          0939-6411
          May 09 2017
          Affiliations
          [1 ] CSIR-Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi 110007, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
          [2 ] CSIR-Indian Institute of Toxicology Research, M.G. Marg, Lucknow -226 001, Uttar Pradesh, India.
          [3 ] CSIR-Indian Institute of Toxicology Research, M.G. Marg, Lucknow -226 001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
          [4 ] CSIR-Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi 110007, India.
          [5 ] CSIR-Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi 110007, India; CSIR-Indian Institute of Toxicology Research, M.G. Marg, Lucknow -226 001, Uttar Pradesh, India; Department of Biological Sciences and Bioengineering (BSBE) and Centre for Environmental Science and Engineering (CESE), Indian Institute of Technology, Kanpur, India. Electronic address: kcgupta9@gmail.com.
          Article
          S0939-6411(16)30437-4
          10.1016/j.ejpb.2017.05.003
          28499854
          d4680201-b3fd-43b1-b82a-2e327cdcc447
          History

          Apoptosis,Autophagy,Cancer,Curcumin,Selenium nanoparticles
          Apoptosis, Autophagy, Cancer, Curcumin, Selenium nanoparticles

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