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      Serum Inhibin as an Index of Ovarian Function in Women Undergoing Pituitary Suppression and Ovarian Stimulation in an in vitro Fertilization Program

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          Abstract

          Serum inhibin concentrations, determined by radioimmunoassay, were measured in women undergoing pituitary suppression with buserelin and subsequently ovarian stimulation with human menopausal gonadotropin (hMG). Three types of treatment cycle were investigated, namely (1) cycles showing a normal ovarian response and resulting in a pregnancy; (2) cycles showing a poor response to the hMG, and (3) cycles previously showing a poor ovarian response but augmented with biosynthetic human growth hormone. Good correlations were seen between serum inhibin concentrations and serum progesterone in the luteal phase prior to buserelin (R<sub>s</sub> = 0.68), serum oestradiol on the 8th day of hMG administration (R<sub>s</sub> = 0.82) or the day of ovulatory trigger (R<sub>s</sub> = 0.78), and the number of follicles ≧ 14 mm on the day of ovulatory trigger (R<sub>s</sub> = 0.71). These results show inhibin to be a good index of ovarian function in women exhibiting a range of ovarian responses to stimulation in an in vitro fertilization program.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1991
          1991
          02 December 2008
          : 35
          : 5
          : 173-177
          Affiliations
          aRegional IVF Unit, St Mary’s Hospital, Manchester, and bReproduction Research Group, Physiological Sciences, University of Manchester, UK
          Article
          181897 Horm Res 1991;35:173–177
          10.1159/000181897
          1802818
          © 1991 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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