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      Cytokeratin 20 immunocytochemistry on urine sediments: A potential low-cost adjunct to cytology in the diagnosis of low-grade urothelial carcinoma.

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          Abstract

          Urine cytology is the corner-stone for the diagnosis of urothelial neoplasia; however, a substantial proportion of low-grade carcinomas are reported as inconclusive owing to scant cellularity and subtle cytological features. Biomarkers applied on urine sediment smears of such patients are likely to be clinically relevant. Access to Food and Drug Administration approved urinary biomarkers in resource limited setting is poor. Detection of cytokeratin 20 (CK20) in urine sediments, although still a research tool, is a promising marker as immunocytochemistry is performed regularly in several Indian laboratories.

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          Author and article information

          Journal
          Cytopathology
          Cytopathology : official journal of the British Society for Clinical Cytology
          Wiley
          1365-2303
          0956-5507
          Dec 2017
          : 28
          : 6
          Affiliations
          [1 ] Department of Pathology, University College of Medical Sciences, University of Delhi, Shahdra, Delhi, India.
          Article
          10.1111/cyt.12463
          28940433
          d48977ac-76f8-4285-88bb-b3ea9057f41f
          History

          urine,cytology,urothelial carcinoma,cytokeratin 20
          urine, cytology, urothelial carcinoma, cytokeratin 20

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