Plasma Lipids, Lipoproteins and Apolipoproteins AI, All, and B in Renal Transplanted Children: What Risk for Accelerated Atherosclerosis?

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Abstract

The aim of the study was to investigate the atherosclerosis risk factors related to hyperlipidemia in renal transplanted children. Plasma cholesterol, triglycerides, apolipoproteins (Apo) AI, All and B, and the major lipoprotein classes separated by gradient ultracentrifugation were compared in 30 renal transplanted patients and 14 healthy children. Hyperlipidemia was present in 66% of the transplanted children. ‘Positive’ risk factors for atherosclerosis (high plasma cholesterol and Apo B) were present in hypercholesterolemic and combined hyperlipidemic subgroups. All transplanted children, whether normo- or hyperlipidemic, presented essentially ‘negative’ risk factors for atherosclerosis, i.e. significantly higher levels of Apo AI and All in plasma and in high-density lipoprotein HDL<sub>2</sub> and higher Apo AI/Apo B and/or Apo AII/B ratios. Repeated evaluations (over a 12-month period) in transplanted children indicated relatively frequent individual changes in the lipid pattern, but not in Apo AI and All content. These results suggest that the risks for accelerated atherosclerosis related to hyperlipidemia may be considered as moderate in transplanted children.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1984

Publication date (Print): 1984

Publication date (Electronic): 04 December 2008

Volume: 38

Issue: 2

Pages: 87-92

Affiliations

^aUnité de Recherches sur le Métabolisme des Lipides, Inserm U. 35, Hôpital Henri Mondor, Créteil; ^bUnité de Recherches sur les Maladies Rénales de l’Enfant, Inserm U. 192, Hôpital des Enfants Malades, Département Pédiatrie, Paris, France

Article

Publisher ID: 183287 Other ID: Nephron 1984;38:87–92

DOI: 10.1159/000183287

PubMed ID: 6433214

SO-VID: d4a1d018-661c-4837-a12d-e8f1c129a96b

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 17 January 1984

Page count

Pages: 6

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