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      Elevated Thrombocyte Calcium Content in Uremia and Its Correction by 1α(OH) Vitamin D Treatment

      , ,

      Nephron

      S. Karger AG

      Uremia, Vitamin D, Thrombocytes, Calcium, Hyperparathyroidism

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          Abstract

          Intracellular calcium plays an important role in the regulation of platelet function. It has also been demonstrated that platelet functions are impaired in uremia. A rise in intracellular calcium has been shown in several tissues and has been held responsible for the impaired function of several organs seen in uremia. This study was undertaken to evaluate whether the calcium (Ca) content of thrombocytes is elevated in uremia and, if so, whether treatment with an active vitamin D metabolite might correct this abnormality. In 10 patients on chronic hemodialysis, platelet Ca content was determined by a technique utilizing consecutive freezing and thawing of platelet-rich plasma. The platelet Ca content of uremic patients was found to be markedly higher (20.86 ± 0.9 ng/200,000 platelets, p < 0.001) than that of a group of 20 normals (12.8 ± 1.2 ng/200,000 platelets). 1 month after treatment with 1α(OH) vitamin D at a dosage of 0.5–2.5 µg/day, the platelet Ca content of the dialysis patients decreased to 14.99 ± 2.14 ng/200,000 platelets (p < 0.05). The data show that in dialysis patients the platelet Ca content is markedly elevated in comparison with that of normals, and that treatment with 1α(OH) vitamin D may significantly reverse this abnormality. It is suggested that elevated Ca content may play a role in the pathogenesis of uremic platelet dysfunction, and that 1α(OH) vitamin D administration may be of benefit in correcting this disorder.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1982
          1982
          03 December 2008
          : 30
          : 3
          : 237-239
          Affiliations
          Hasharon Hospital, Petah Tikva, Israel; Tel Aviv University Medical School, Tel Aviv, Israel
          Article
          182471 Nephron 1982;30:237–239
          10.1159/000182471
          7099335
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 3
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Hyperparathyroidism, Vitamin D, Thrombocytes, Uremia, Calcium

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