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      Elevated Thrombocyte Calcium Content in Uremia and Its Correction by 1α(OH) Vitamin D Treatment

      , ,


      S. Karger AG

      Uremia, Vitamin D, Thrombocytes, Calcium, Hyperparathyroidism

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          Intracellular calcium plays an important role in the regulation of platelet function. It has also been demonstrated that platelet functions are impaired in uremia. A rise in intracellular calcium has been shown in several tissues and has been held responsible for the impaired function of several organs seen in uremia. This study was undertaken to evaluate whether the calcium (Ca) content of thrombocytes is elevated in uremia and, if so, whether treatment with an active vitamin D metabolite might correct this abnormality. In 10 patients on chronic hemodialysis, platelet Ca content was determined by a technique utilizing consecutive freezing and thawing of platelet-rich plasma. The platelet Ca content of uremic patients was found to be markedly higher (20.86 ± 0.9 ng/200,000 platelets, p < 0.001) than that of a group of 20 normals (12.8 ± 1.2 ng/200,000 platelets). 1 month after treatment with 1α(OH) vitamin D at a dosage of 0.5–2.5 µg/day, the platelet Ca content of the dialysis patients decreased to 14.99 ± 2.14 ng/200,000 platelets (p < 0.05). The data show that in dialysis patients the platelet Ca content is markedly elevated in comparison with that of normals, and that treatment with 1α(OH) vitamin D may significantly reverse this abnormality. It is suggested that elevated Ca content may play a role in the pathogenesis of uremic platelet dysfunction, and that 1α(OH) vitamin D administration may be of benefit in correcting this disorder.

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          Author and article information

          S. Karger AG
          03 December 2008
          : 30
          : 3
          : 237-239
          Hasharon Hospital, Petah Tikva, Israel; Tel Aviv University Medical School, Tel Aviv, Israel
          182471 Nephron 1982;30:237–239
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 3
          Original Paper

          Cardiovascular Medicine, Nephrology

          Hyperparathyroidism, Vitamin D, Thrombocytes, Uremia, Calcium


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