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Abstract
Starting with a test statistic for linkage analysis based on allele sharing, we propose
an associated one-parameter model. Under general missing-data patterns, this model
allows exact calculation of likelihood ratios and LOD scores and has been implemented
by a simple modification of existing software. Most important, accurate linkage tests
can be performed. Using an example, we show that some previously suggested approaches
to handling less than perfectly informative data can be unacceptably conservative.
Situations in which this model may not perform well are discussed, and an alternative
model that requires additional computations is suggested.