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      Allele-Sharing Models: LOD Scores and Accurate Linkage Tests

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      The American Journal of Human Genetics
      University of Chicago Press

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          Abstract

          Starting with a test statistic for linkage analysis based on allele sharing, we propose an associated one-parameter model. Under general missing-data patterns, this model allows exact calculation of likelihood ratios and LOD scores and has been implemented by a simple modification of existing software. Most important, accurate linkage tests can be performed. Using an example, we show that some previously suggested approaches to handling less than perfectly informative data can be unacceptably conservative. Situations in which this model may not perform well are discussed, and an alternative model that requires additional computations is suggested.

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          Author and article information

          Journal
          The American Journal of Human Genetics
          The American Journal of Human Genetics
          University of Chicago Press
          00029297
          November 1997
          November 1997
          : 61
          : 5
          : 1179-1188
          Article
          10.1086/301592
          1716027
          9345087
          d4b3e62f-fc6d-40ad-af20-824c3076ded4
          © 1997

          https://www.elsevier.com/tdm/userlicense/1.0/

          http://www.elsevier.com/open-access/userlicense/1.0/

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