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      The role of the endothelial dependent relaxing factor in the regulation of cerebral circulation Translated title: Papel do fator relaxante endotelial na circulação sanguínea cerebral

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      Arquivos de Neuro-Psiquiatria
      Academia Brasileira de Neurologia - ABNEURO

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          Abstract

          It has recently been demonstrated that vessel dilation induced by several physiological agents is dependent on an intact vascular endothelium. In order to explain this endothelium dependence, it has been hypothesized that a still unknown chemical substance, generically named Endothelium Dependent Relaxing Factor (EDRF) is necessary for physiological vasodilation. The role of this EDRF in the cerebrovascular physiology is not yet well understood. In this article the cerebrovascular physiological control is reviewed in relationship with possible EDRF actions. The importance of endothelial lesions in the cerebrovascular responses is discussed.

          Translated abstract

          Recentemente foi descoberto que o endotélio vascular deve estar intacto para que vasos sanguíneos dilatem quando estimulados por agentes fisiológicos. Acredita-se que uma substância química ainda desconhecida, genericamente chamada Fator Relaxante Endotelial (FRE), produzida pelo endotélio, é indispensável para o relaxamento vascular. Neste trabalho é revista a fisiologia circulatória cerebral e possíveis ações do FRE. Discute-se também a importância de lesões endoteliais em relação ao controle circulatório cerebral.

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          Most cited references66

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          Role of endothelium in responses of vascular smooth muscle.

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            The biology of oxygen radicals.

            The reactive superoxide radical, O2-, formerly of concern only to radiation chemists and radiobiologists, is now understood to be a normal product of the biological reduction of molecular oxygen. An unusual family of enzymes, the superoxide dismutases, protect against the deleterious actions of this radical by catalyzing its dismutation to hydrogen peroxide plus oxygen.
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              Circulation and metabolism of the human brain in health and disease.

              S KETY (1950)
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                Author and article information

                Contributors
                Role: ND
                Journal
                anp
                Arquivos de Neuro-Psiquiatria
                Arq. Neuro-Psiquiatr.
                Academia Brasileira de Neurologia - ABNEURO (São Paulo )
                1678-4227
                March 1988
                : 46
                : 1
                : 90-97
                Article
                S0004-282X1988000100016
                10.1590/S0004-282X1988000100016
                d4bc496a-cf93-48a2-93c7-efbcf9354953

                http://creativecommons.org/licenses/by/4.0/

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                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0004-282X&lng=en
                Categories
                NEUROSCIENCES
                PSYCHIATRY

                Neurosciences,Clinical Psychology & Psychiatry
                Neurosciences, Clinical Psychology & Psychiatry

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