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      The Carbohydrate Reserve in the Vitreous Body and Retina of the Rabbit’s Eye during and after Pressure Ischaemia and Insulin Hypoglycaemia

      Ophthalmic Research

      S. Karger AG

      Retinal metabolism, Anaerobic glycolysis, Ischaemia, Hypoglycaemia, Recovery time, ERG

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          Abstract

          The glucose and glycogen content of the vitreous body and retina of rabbits’ eyes were estimated in pressure ischaemia and insulin hypoglycaemia. During 1 h of ‘pressure ischaemia’ two thirds of the substrate required for maintaining anaerobic glycolysis was supplied from the vitreous body. It was demonstrated by a model experiment that the energy reserves of the vitreous body were consumed by the retina exclusively. One of the factors limiting the recovery time of the retina is the decline of anaerobic glycolysis and not the exhaustion of the glucose reserve. A possible correlation with the recovery time of the ERG is discussed. There is no relation between the replenishment of the carbohydrate reserve and the normalisation of the ERG.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1972
          1972
          09 December 2009
          : 3
          : 6
          : 360-371
          Affiliations
          I. Eye Clinic and Department of Experimental Ophthalmology, University of Vienna (Dir.Prof.Dr. K. Hruby)
          Article
          266229 Ophthal Res 1972;3:360–371
          10.1159/000266229
          © 1972 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 12
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