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      Evidence That Cell Bodies in the Arcuate Nucleus of the Hypothalamus Are Not Cholinergic

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          Abstract

          Central cholinergic pathways have been implicated in the control of pituitary hormone release. Based on studies using acetylcholinesterase (AChE) histochemistry, it has been proposed that the cholinergic neurons controlling hormone release originate in neurons of the arcuate nucleus (AH). Although AChE histochemistry has been widely utilized to map central cholinergic pathways, AChE is not an unequivocal marker for cholinergic neurons. A more precise method for determining that neurons are cholinergic is the immunocytochemical labeling of choline acetyltransferase (CAT). In order to determine if the AChE-positive neurons in the AH are cholinergic, we double-labeled tissue sections for CAT and AChE using a combined immunocytochemical and AChE-histochemical method. Although neurons in several areas of the brain could be labeled for both CAT and AChE, neurons in the AH were only AChE-positive. We concluded that the AChE-positive neurons in the AH may be cholinoceptive but are not likely to be the source of cholinergic neurons controlling hormone release from the pituitary gland.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1985
          1985
          28 March 2008
          : 41
          : 5
          : 427-431
          Affiliations
          Department of Anatomy, University of Nebraska Medical Center, and The Boys Town National Institute for Communication Disorders in Children, Omaha, Nebr., USA
          Article
          124213 Neuroendocrinology 1985;41:427–431
          10.1159/000124213
          4058675
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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