Blog
About

27
views
0
recommends
+1 Recommend
1 collections
    1
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Cangumycins A−F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Cangumycins A−F ( 16), six new angucyclinone analogues, together with two known ones ( 7 and 8), were isolated from the fermentation broth of a soil-derived Streptomyces sp. KIB-M10. Structures of these compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Among them, cangumycins E ( 5) and F ( 6) share a C-ring cleaved backbone, and cangumycins B ( 2) and E ( 5) exhibit potent immunosuppressive activity (IC 50 8.1 and 2.7 μmol·L −1, respectively) against human T cell proliferation at a non-cytotoxic concentration.

          Related collections

          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier BV
          1875-5364
          20 December 2019
          : 17
          : 12
          : 982-987
          Affiliations
          1 State Key Laboratory of Phytochemistry and Plant Resources in West China, and CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
          2 College of Chemistry and Pharmacy, Northwest Agriculture and Forestry University, Yangling 712100, China
          3 Research Center, Chengdu Medical College, Chengdu 610500, China
          4 Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China
          Author notes
          *Corresponding author: HUANG Sheng-Xiong, Tel/Fax: 86-871-65215112, E-mail: sxhuang@ 123456mail.kib.ac.cn

          Δ These authors contributed equally to this work.

          These authors have no conflict of interest to declare.

          Dedicated to Professor SUN Han-Dong on the Occasion of His 80th Birthday

          Article
          S1875-5364(19)30121-9
          10.1016/S1875-5364(19)30121-9
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: U1702285
          Funded by: National Natural Science Foundation of China
          Award ID: 81522044
          Funded by: Natural Science Foundation of Yunnan Province
          Award ID: 2016FA003
          Funded by: State key laboratory of phytochemistry and plant resource in west China
          Award ID: P2018-KF03
          Funded by: Key Research Program of Frontier Sciences and the Strategic Priority Research Program, CAS
          Award ID: QYZDB-SSW-SMC051
          Funded by: Key Research Program of Frontier Sciences and the Strategic Priority Research Program, CAS
          Award ID: XDB27020205
          This work was supported by the National Natural Science Foundation of China (Nos. U1702285 and 81522044), Natural Science Foundation of Yunnan Province (No. 2016FA003), the State key laboratory of phytochemistry and plant resource in west China (No. P2018-KF03), Key Research Program of Frontier Sciences and the Strategic Priority Research Program, CAS (Nos. QYZDB-SSW-SMC051 and XDB27020205).
          Categories
          Research article

          Comments

          Comment on this article