Blog
About

0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      A novel approach for addressing diseases not yielding to effective vaccination? Immunization by replication-competent controlled virus.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Vaccination involves inoculation of a subject with a disabled disease-causing microbe or parts thereof. While vaccination has been highly successful, we still lack sufficiently effective vaccines for important infectious diseases. We propose that a more complete immune response than that elicited from a vaccine may be obtained from immunization with a disease-causing virus modified to subject replication-essential genes to the control of a gene switch activated by non-lethal heat in the presence of a drug-like compound. Upon inoculation, strictly localized replication of the virus would be triggered by a heat dose administered to the inoculation site. Activated virus would transiently replicate with an efficiency approaching that of the disease-causing virus and express all viral antigens. It may also vector heterologous antigens or control co-infecting microbes.

          Related collections

          Author and article information

          Affiliations
          [1 ] Department of Physiological Sciences, University of Florida College of Veterinary Sciences, Gainesville, FL, USA.
          Journal
          Expert Rev Vaccines
          Expert review of vaccines
          Informa UK Limited
          1744-8395
          1476-0584
          May 2015
          : 14
          : 5
          10.1586/14760584.2015.1013941
          25676927

          Comments

          Comment on this article