4
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Simulation and conceptual design of a dl-methionine production process by the chemical synthesis route Translated title: Simulación y diseño conceptual de un proceso de producción de dl-metionina por la ruta de síntesis química Translated title: Simulação e projeto conceitual de processo de produção de dl-metionina através da rota de síntese química

      research-article

      Read this article at

      SciELO
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Abstract Methionine is one of the two sulfur-containing amino acids demanded in the diet of humans, other mammals and avian species, while most of the produced methionine is consumed as an animal feed additive, especially in livestock production and the poultry market. In this paper, the techno-economic assessment and conceptual design of an industrial scale, feed grade dl-methionine production process was carried out using SuperPro Designer® simulator. The plant was designed to produce 109 tons of dl-methionine per year through the chemical synthesis route. The total capital investment and annual operating cost of the proposed plant were USD \(8.282 million and USD \) 1.323 million, respectively, while the net present value, the internal rate of return and payback time of the project were USD \(4.436 million, 20.33 % and 4.74 years, respectively. The findings indicated that the proposed production process is feasible and profitable for a dl-methionine selling price of USD \) 35/kg. The innovative simulation model obtained in this work could be used for further optimization studies, as well as to increase the productivity and profitability of the proposed plant.

          Translated abstract

          Resumen La metionina es uno de los dos aminoácidos que contienen azufre requeridos en la dieta de humanos, otros mamíferos y especies aviares, mientras que la mayoría de la metionina producida es usada como aditivos de alimento animal, especialmente en la producción de ganado y el mercado avícola. En este artículo, se llevó a cabo la evaluación técnico-económica y diseño conceptual de un proceso de producción de dl-metionina de grado alimenticio a escala industrial usando el simulador SuperPro Designer®. La planta fue diseñada para producir 109 t de dl-metionina por año a través de la ruta de la síntesis química. La inversión total de capital y el costo anual de operación de la planta propuesta fueron de USD \(8,282 millones y USD \) 1,323 millones, respectivamente, mientras que el valor actual neto, la tasa interna de retorno y el periodo de recuperación de la inversión del proyecto fueron de USD \(4,436 millones, 20,33 % y 4,74 años, respectivamente. Los hallazgos indicaron que el proceso de producción propuesto es factible and rentable para un precio de venta de la dl-metionina de USD \) 35/kg. El modelo de simulación innovador obtenido en este trabajo puede usarse para estudios de optimización posteriores, así como también para incrementar la productividad y rentabilidad de la planta propuesta.

          Translated abstract

          Resumo A metionina é um dos dois aminoácidos contendo enxofre necessário na dieta de humanos, outros mamíferos e espécies aviárias, enquanto a maior parte da metionina produzida é usada como aditivos na alimentação animal, especialmente na produção pecuária e no mercado avícola. Neste artigo foi realizada a avaliação técnico-econômica e o projeto conceitual de um processo de produção de dl-metionina de qualidade alimentar em escala industrial utilizando o simulador SuperPro Designer®. A planta foi projetada para produzir 109 t de dl-metionina por ano por meio de síntese química. O investimento total de capital e o custo operacional anual da planta proposta foram de US\(8,282 milhões e US\) 1,323 milhões, respectivamente, enquanto o valor presente líquido, a taxa interna de retorno e o período de retorno do projeto da planta proposta foram de US\(4,436 milhões, 20,33% e 4,74 anos, respectivamente. As descobertas indicaram que o processo de produção proposto é viável e rentável para um preço de venda de dl-metionina de US\) 35/kg. O inovador modelo de simulação obtido neste trabalho poderá ser utilizado para posteriores estudos de optimização, bem como para aumentar a produtividade e lucratividade da planta proposta.

          Related collections

          Most cited references36

          • Record: found
          • Abstract: not found
          • Book: not found

          Plant design and economics for chemical engineers

            • Record: found
            • Abstract: found
            • Article: not found

            Methionine production by fermentation.

            Fermentation processes have been developed for producing most of the essential amino acids. Methionine is one exception. Although microbial production of methionine has been attempted, no commercial bioproduction exists. Here, we discuss the prospects of producing methionine by fermentation. A detailed account is given of methionine biosynthesis and its regulation in some potential producer microorganisms. Problems associated with isolation of methionine overproducing strains are discussed. Approaches to selecting microorganism having relaxed and complex regulatory control mechanisms for methionine biosynthesis are examined. The importance of fermentation media composition and culture conditions for methionine production is assessed and methods for recovering methionine from fermentation broth are considered.
              • Record: found
              • Abstract: found
              • Article: not found

              Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum.

              Metabolic pathway analysis was carried out to predict the metabolic potential of Corynebacterium glutamicum and Escherichia coli for the production of L-methionine. Based on detailed stoichiometric models for these organisms, this allowed the calculation of the theoretically optimal methionine yield and related metabolic fluxes for various scenarios involving different mutants and process conditions. The theoretical optimal methionine yield on the substrates glucose, sulfate and ammonia for the wildtype of C. glutamicum is 0.49 (C-mol) (C-mol)(-1), whereas the E. coli wildtype exhibits an even higher potential of 0.52 (C-mol) (C-mol)(-1). Both strains showed completely different optimal flux distributions. C. glutamicum has a high flux through the pentose phosphate pathway (PPP), whereas the TCA cycle flux is very low. Additionally, it recruits a metabolic cycle, which involves 2-oxoglutarate and glutamate. In contrast, E. coli does minimize the flux through the PPP, and the flux through the TCA cycle is high. The improved potential of the E. coli wildtype is due to its membrane-bound transhydrogenase and its glycine cleavage system as shown by additional simulations with theoretical mutants. A key point for maximizing methionine yield is the choice of the sulfur source. Replacing sulfate by thiosulfate or sulfide increased the maximal theoretical yield in C. glutamicum up to 0.68 (C-mol) (C-mol)(-1). A further increase is possible by the application of additional C1 sources. The highest theoretical potential was obtained for C. glutamicum applying methanethiol as combined source for C1 carbon and sulfur (0.91 (C-mol) (C-mol)(-1)). Substrate requirement for maintenance purposes reduces theoretical methionine yields. In the case of sulfide used as sulfur source a maintenance requirement of 9.2 mmol ATP g(-1) h(-1), as was observed under stress conditions, would reduce the maximum theoretical yield from 67.8% to 47% at a methionine production rate of 0.65 mmol g(-1) h(-1). The enormous capability of both organisms encourages the development of biotechnological methionine production, whereby the use of metabolic pathway analysis, as shown, provides valuable advice for future strategies in strain and process improvement.

                Author and article information

                Journal
                rion
                Revista ION
                Rev. ion
                Universidad Industrial de Santander (Bucaramanga, Santander, Colombia )
                0120-100X
                2145-8480
                April 2024
                : 37
                : 1
                : 65-81
                Affiliations
                [1] Camagüey Camagëy orgnameUniversidad de Camagüe orgdiv1Facultad de Ciencias Aplicadas Cuba
                [2] Villa Clara Villa Clara orgnameUniversidad Central Marta Abreu de las Villas orgdiv1Facultad de Química y Farmacia Cuba
                [3] Ciego de Ávila orgnameEmpresa Servicios Automotores S.A. Cuba
                Author information
                https://orcid.org/0000-0002-0819-6760
                https://orcid.org/0000-0002-3193-0660
                https://orcid.org/0000-0002-7656-5476
                https://orcid.org/0000-0001-9755-0276
                https://orcid.org/0000-0003-4481-1262
                Article
                S0120-100X2024000100065 S0120-100X(24)03700100065
                10.18273/revion.v37n1-2024005
                d4eba1b9-af2f-40c8-af25-5e4d10730d4a

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 29 October 2023
                : 20 May 2024
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 36, Pages: 17
                Product

                SciELO Colombia

                Categories
                Articles

                Avaliação técnico-econômica,Dl-methionine,Process simulation,Profitability indicators,SuperPro Designer®,Techno-economic evaluation,Dl-metionina,Simulación de procesos,Indicadores de rentabilidad,Evaluación técnico-económica,Simulação de processos,Indicadores de rentabilidade

                Comments

                Comment on this article

                Related Documents Log