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      Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activity.

      Arthritis and Rheumatism

      Adult, Aged, Antigens, CD44, genetics, Biological Markers, Disease Progression, Female, Gene Expression, immunology, Genetic Markers, Genetic Variation, Humans, Lupus Erythematosus, Systemic, physiopathology, Male, Middle Aged, Multivariate Analysis, Regression Analysis, T-Lymphocytes, Young Adult

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          Abstract

          To quantify the expression of CD44 and variant isoforms CD44v3 and CD44v6 on T cells from patients with systemic lupus erythematosus (SLE), and to assess correlations of the level of expression of these molecules with disease manifestations. Information on clinical and demographic characteristics was collected, and blood samples were obtained from 72 patients with SLE and 32 healthy control subjects matched to the patients by sex, race, and age. Expression of CD44 and variants CD44v3 and v6 on T cell subsets was determined by flow cytometry, and Pearson's correlations of their expression levels with clinical variables, SLE Disease Activity Index (SLEDAI) scores, and presence of lupus nephritis were determined. Wilcoxon's rank sum tests and conditional multivariable regression analyses were applied to identify differences in the expression of CD44 between patients with SLE and healthy controls. Expression of CD44 was higher on CD4+ and CD8+ T cells from SLE patients compared with controls (P

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          Author and article information

          Journal
          20213807
          2879041
          10.1002/art.27385

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