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      Testing Renal Reserve Filtration Capacity with an Amino Acid Solution

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          Abstract

          In healthy individuals and in patients with varying degrees of impaired renal function, glomerular filtration rate (GFR) and effective renal plasma now were measured before and during infusion of an amino acid solution (Vamin®N). GFR increased during amino acid infusion in healthy individuals while the filtration fraction (FF) remained constant. However, in patients with impaired renal function no significant changes in GFR were observed. The FF increased slightly. We conclude that amino acid infusion can increase GFR, possibly by utilization of ‘dormant cortical nephrons’ together with a rise in net ultrafiltration pressure of other filtrating glomeruli, both due to afferent vasodilatation. Thus, amino acid administration can be used to test the presence of reserve filtration capacity.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1985
          1985
          04 December 2008
          : 41
          : 2
          : 193-199
          Affiliations
          Department of Internal Medicine, University Hospital, Groningen, The Netherlands
          Article
          183580 Nephron 1985;41:193–199
          10.1159/000183580
          4047278
          © 1985 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 7
          Categories
          Original Paper

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