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      Strategies to improve performances of LSPR biosensing: Structure, materials, and interface modification

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      Biosensors and Bioelectronics
      Elsevier BV

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          Abstract

          Due to the unique nature of localized surface plasmon resonance (LSPR), LSPR has attracted extensive attention in the field of biochemical sensing. However, compared with other sensors, the LSPR biosensor has lower sensitivity which has the limitation of insufficient repeatability and greatly limits its application and further promotion. Many researchers have invested a lot of energy in various ways to investigate different methods to improve sensitivity. This review summarizes these methods from the three aspects of structure, material, and interface modification. Meanwhile, it can be predicted that the strategies to improve the performance of LSPR biosensing will extend its application.

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          Metamaterials and negative refractive index.

          Recently, artificially constructed metamaterials have become of considerable interest, because these materials can exhibit electromagnetic characteristics unlike those of any conventional materials. Artificial magnetism and negative refractive index are two specific types of behavior that have been demonstrated over the past few years, illustrating the new physics and new applications possible when we expand our view as to what constitutes a material. In this review, we describe recent advances in metamaterials research and discuss the potential that these materials may hold for realizing new and seemingly exotic electromagnetic phenomena.
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            Gold nanoparticles in chemical and biological sensing.

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              Present and Future of Surface-Enhanced Raman Scattering

              The discovery of the enhancement of Raman scattering by molecules adsorbed on nanostructured metal surfaces is a landmark in the history of spectroscopic and analytical techniques. Significant experimental and theoretical effort has been directed toward understanding the surface-enhanced Raman scattering (SERS) effect and demonstrating its potential in various types of ultrasensitive sensing applications in a wide variety of fields. In the 45 years since its discovery, SERS has blossomed into a rich area of research and technology, but additional efforts are still needed before it can be routinely used analytically and in commercial products. In this Review, prominent authors from around the world joined together to summarize the state of the art in understanding and using SERS and to predict what can be expected in the near future in terms of research, applications, and technological development. This Review is dedicated to SERS pioneer and our coauthor, the late Prof. Richard Van Duyne, whom we lost during the preparation of this article.
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                Author and article information

                Journal
                Biosensors and Bioelectronics
                Biosensors and Bioelectronics
                Elsevier BV
                09565663
                February 2021
                February 2021
                : 174
                : 112850
                Article
                10.1016/j.bios.2020.112850
                33309521
                d50666c1-a526-4841-b56c-5d52f31b82da
                © 2021

                https://www.elsevier.com/tdm/userlicense/1.0/

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