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      Functionalization and optimization-strategy of graphene oxide-based nanomaterials for gene and drug delivery

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          Abstract

          Graphene-family nanomaterials (GFNs) have been widely used in cancer therapy, tissue engineering, antibacterial and biological imaging due to their optical, thermal, and drug absorption properties. When used as drug and gene nanocarrier, the major limitations are aggregation, biocompatibility, and inappropriate release of drugs or genes. To overcome these problems, researchers have developed a variety of functionalization processes. In this review, we grouped the functionalization according to the decoration molecules, putting particular emphasis on the gene delivery. Organic and inorganic materials resulted as the major sets to introduce functional sections onto graphene oxide (GO). We also classified the target molecules used in the GO delivery system, as well as introduced other strategies to increase the delivery efficacy such as controlled release and magnetic targeting.

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          Author and article information

          Journal
          Am J Transl Res
          Am J Transl Res
          ajtr
          American Journal of Translational Research
          e-Century Publishing Corporation
          1943-8141
          2020
          15 May 2020
          : 12
          : 5
          : 1515-1534
          Affiliations
          [1 ] School of Basic and Forensic Medicine, Baotou Medical College Baotou 014040, Inner Mongolia Autonomous Region, P. R. China
          [2 ] Blood Conservation Institute, Baotou Medical College Baotou 014040, Inner Mongolia Autonomous Region, P. R. China
          [3 ] Department of Urology, The First Affiliated Hospital of Wenzhou Medical University, The First Clinical College of Wenzhou Medical University Wenzhou 325000, Zhejiang Province, P. R. China
          [4 ] No. 5 Railway Middle School Baotou, Inner Mongolia Autonomous Region, P. R. China
          Author notes
          Address correspondence to: Dr. Qiang Ma, Blood Conservation Institute, Baotou Medical College, Baotou 014040, Inner Mongolia Autonomous Region, P. R. China. Tel: +86-472-7167841; E-mail: btwztougao@ 123456hotmail.com
          [*]

          Equal contributors.

          Article
          PMC7270027 PMC7270027 7270027
          7270027
          32509159
          d50d4330-6b98-4196-b510-889f5a401822
          AJTR Copyright © 2020
          History
          : 19 September 2019
          : 14 April 2020
          Categories
          Review Article

          Graphene oxide,target delivery,nanocarrier,gene delivery

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