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      Linking endothelial dysfunction with endothelial cell activation.

      The Journal of clinical investigation
      Animals, Endothelial Cells, pathology, physiology, Endothelium, Vascular, physiopathology, Humans, Nitric Oxide, Vascular Cell Adhesion Molecule-1, Vascular Diseases

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          Abstract

          The thin layer of cells that lines the interior of blood vessels, known as the endothelium, plays a complex role in vascular biology. The endothelium mediates blood vessel tone, hemostasis, neutrophil recruitment, hormone trafficking, and fluid filtration. Endothelial dysfunction, as defined by a lack of NO, has been linked to a variety of disease states, including atherosclerosis, diabetes mellitus, coronary artery disease, hypertension, and hypercholesterolemia. Indeed, restoration of endothelial function is one of the earliest recognizable benefits of statin therapy. In 1995, James Liao and colleagues published a study in the JCI demonstrating that NO is a vascular protective factor that limits endothelial activation and prevents leukocyte adhesion to the vessel wall.

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          Author and article information

          Journal
          23485580
          3561809
          10.1172/JCI66843

          Chemistry
          Animals,Endothelial Cells,pathology,physiology,Endothelium, Vascular,physiopathology,Humans,Nitric Oxide,Vascular Cell Adhesion Molecule-1,Vascular Diseases

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