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      Call for Papers: Green Renal Replacement Therapy: Caring for the Environment

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      About Blood Purification: 3.0 Impact Factor I 5.6 CiteScore I 0.83 Scimago Journal & Country Rank (SJR)

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      What Have We Learned about the Use of Cytosorb Adsorption Columns?

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          Abstract

          Extracorporeal blood purification techniques have emerged and evolved in the recent years as a potential therapy for the purpose of immunomodulation in acute conditions like sepsis. Understanding the extent of immune system dysregulation involved in the pathophysiology of these conditions, resulted in the development of such treatment strategies aiming at restoring a balanced inflammatory response. Beyond conventional continuous renal replacement therapy, high volume hemofiltration, high cut-off membranes, adsorption alone and coupled plasma filtration adsorption are well-described techniques in the literature. The evidence to support their routine use, however, is conflicting and insufficient at this stage. Despite the low-quality level of evidence in favor of utilizing these techniques, studies to further explore their effectiveness, safety, and potential novel applications, continue to evolve. Our review aims at focusing on adsorption therapy, particularly using the adsorption columns Cystosorb.

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          Author and article information

          Journal
          BPU
          Blood Purif
          10.1159/issn.0253-5068
          Blood Purification
          S. Karger AG
          0253-5068
          1421-9735
          2019
          October 2019
          30 April 2019
          : 48
          : 3
          : 196-202
          Affiliations
          [_a] aIRRIV, International Renal Research Institute Vicenza, Vicenza, Italy
          [_b] bDepartment of Internal Medicine and Nephrology, King Abdulaziz University, Jeddah, Saudi Arabia
          [_c] cDepartment of Nephrology Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
          [_d] dDepartment of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
          [_e] eDepartment of Nephrology, Molecular Cell Laboratory for Kidney Disease, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
          [_f] fDepartment of Nephrology, Southwest Hospital, First Affiliated Hospital to TMMU, Third Military Medical University (Army Medical University), Chongqing, China
          [_g] gDepartment of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, Italy
          Author notes
          *Ghada Ankawi, International Renal Research Institute Vicenza (IRRIV), San Bortolo Hospital, Viale Rodolfi 37, IT–36100 Vicenza (Italy), E-Mail ghadaankawi@gmail.com
          Article
          500013 Blood Purif 2019;48:196–202
          10.1159/000500013
          31039564
          d51a7a60-14c9-4506-bf0e-ebfc01fde6d2
          © 2019 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 08 January 2019
          : 29 March 2019
          Page count
          Figures: 1, Tables: 2, Pages: 7
          Categories
          Review

          Cardiovascular Medicine,Nephrology
          Cytokines,Cardiac surgery,Adsorption,Extracorporeal therapy,Sepsis,Sorbents

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