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      Leptina: un péptido con potencial terapéutico en sujetos obesos

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          Abstract

          Obesity is the result of a positive balance between total energy intake and its catabolism. Although many factors are involved in the regulation of energy metabolism, the discovery of leptin led to energy homeostasis being investigated in greater depth. Since its identification, leptin has been considered important in the development of obesity, given its anorexigenic effect and influence on food intake and energy expenditure. Leptin is involved in diverse physiological processes such as energy balance, appetite and body weight control, fat and carbohydrate metabolism, and reproduction. However, to be able to function, this hormone has many specific receptors both centrally (hypothalamus) and peripherally in the skeletal muscle, lungs and kidneys. This study aims to review the key aspects relating leptin to the development of obesity and discusses its potential as an anorectic agent. Copyright 2009 SEEN. Published by Elsevier Espana. All rights reserved.

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          Author and article information

          Journal
          Endocrinología y Nutrición
          Endocrinología y Nutrición
          Elsevier BV
          15750922
          August 2010
          August 2010
          : 57
          : 7
          : 322-327
          Article
          10.1016/j.endonu.2010.03.018
          20605117
          d520d8f1-641d-4122-b7c3-6c38cec05b40
          © 2010

          https://www.elsevier.com/tdm/userlicense/1.0/

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