Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

Investigations of the mechanism of membrane activity of selected triterpenoid saponins.

1 , ,

Planta medica

Thieme Publishing Group

Read this article at

ScienceOpenPublisherPubMed
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      The experiments with different triterpenoid saponins showed a significant difference in the microphysiometric activity between acylated and non-acylated compounds. Only acylated saponins in low concentrations were able to activate the metabolism of endothelial cells after short-time incubation in a transient manner lasting approximately 2 hours. The strongest effect was produced by virgaureasaponin b, an incubation with 4 microg/ml over 6 min induced a stimulation of the metabolic activity of 190% maximum after 30 min. This treatment did not induce non-reversible toxic effects, and could be repeated in the same way after a recovery period. The saponins without acylation in the glycosidic part did not induce metabolic stimulation, even in concentrations higher than observed for the acylated compounds. The current interpretation of the results is connected with the suggestion that especially acylated saponins are able to integrate into the cellular membrane transiently. This integration might induce pore-like structures which change the membrane permeability associated with alterations in the ionic homeostasis between intracellular and extracellular compartments.

      Related collections

      Author and article information

      Affiliations
      [1 ] Institut für Pharmazie, Humboldt-Universität zu Berlin, Germany. matthias.f.melzig@rz.hu-berlin.de
      Journal
      Planta Med.
      Planta medica
      Thieme Publishing Group
      0032-0943
      0032-0943
      Feb 2001
      : 67
      : 1
      11270721
      10.1055/s-2001-10632

      Comments

      Comment on this article