Immunization with cytolethal distending toxin B produces autoantibodies to vinculin and small bowel bacterial changes in a rat model of postinfectious irritable bowel syndrome.

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Abstract

Recent data substantiate the importance of acute gastroenteritis in the development of irritable bowel syndrome (IBS). An animal model of postinfectious IBS determined the importance of cytolethal distending toxin B (CdtB) during live Campylobacter jejuni infection and its development of autoimmunity to vinculin. In this study, we examine whether subcutaneous exposure to CdtB alone is sufficient to produce the postinfectious IBS effect and autoimmunity.

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Journal

Journal ID (iso-abbrev): Neurogastroenterol Motil

Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

Publisher: Wiley

ISSN (Electronic): 1365-2982

ISSN (Print): 1350-1925

Publication date (Electronic): October 2020

Volume: 32

Issue: 10

Affiliations

[1 ] Medically Associated Science and Technology (MAST) Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

[2 ] Hepatogastroenterology Unit, 2nd Department of Internal Medicine - Propaedeutic, Research Institute and Diabetes Center, Medical School, Attikon University General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

[3 ] Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, South Korea.

Article

DOI: 10.1111/nmo.13875

PubMed ID: 32436301

SO-VID: d5396666-8867-449b-8b44-11d428cbe004

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Keywords: vinculin,rat model,postinfectious irritable bowel syndrome,cytolethal distending toxin B,autoimmunity

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Keywords: vinculin, rat model, postinfectious irritable bowel syndrome, cytolethal distending toxin B, autoimmunity

Immunization with cytolethal distending toxin B produces autoantibodies to vinculin and small bowel bacterial changes in a rat model of postinfectious irritable bowel syndrome.

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