Sir,
An 8-month-old female child, born out of non-consanguineous marriage, developmentally
normal for age, immunized appropriately presented with complaints of fever on and
off for five months and loose stools for past five days. The fever, however, was never
documented and was intermittent in nature, not associated with any chills and rigors
or any diurnal variation, and used to get relieved on taking oral medications. The
stool frequency was 5–6 episodes per day, watery in nature, non-foul smelling, not
associated with blood in stools. No history of decreased urinary frequency, lethargy,
or increased irritability was found. There were no complaints of increasing pallor,
bleed from any site, abdominal distension, or any history suggestive of recurrent
infections. Birth and antenatal period were uneventful. There was no in-utero exposure
to radiation and no history of maternal smoking. On examination, the child was hemodynamically
stable without any signs of dehydration. Length was 69 cm (b/w 50th and 75th centile),
head circumference 42 cm (−1 SD), and weight was 6 kg (<3rd centile). There was mild
pallor, but no icterus, lymphadenopathy, petechiae, or ecchymosis were found on physical
examination. The abdomen was slightly distended, with presence of bilateral, hard,
ballotable masses. No hepatosplenomegaly was present. The respiratory, cardiovascular,
and central nervous system examination did not reveal any abnormality.
Laboratory examination revealed the following:
Hemoglobin was 9 g/dl, TLC – 1.76 × 103/μl with 80% lymphocytes, platelets – 100 ×
103/μl, urea – 14 mg/dl, creatinine – 0.5 mg/dl, and uric acid – 13.2 g/dl, S. phosphate
– L 6.2 mg/dl, ionized calcium – 4.2 mg/dl, potassium – 2.5 mEq/l, and sodium – 139
mEq/l. Peripheral blood examination showed presence of leucocytosis with peripheral
blast count of 85%; red blood cells were normocytic normochromic. Bone marrow aspiration
confirmed acute lymphoblastic leukemia (ALL) and showed 89% blasts, which were three
times the size of normal lymphocytes, with scant amount of agranular cytoplasm, high
nuclear–cytoplasmic ratio, with presence of opened up fine chromatin, and 0–1 inconspicuous
nucleoli. There was suppression of erythroid, myeloid, and megakaryocyte series. The
blast cells were positive for CD79a, CD19, and HLADR and negative for CD10 and MPO.
Findings on immunophenotyping were consistent with precursor B-cell ALL. Contrast
enhanced computed tomogram of the abdomen revealed presence of bilaterally enlarged
kidneys: left kidney – 10 × 3.5 cm, right kidney – 9.9 × 5.2 cm, normal in contour
and parenchymal attenuation without any hydronephrosis, calculus and with preserved
cortico-medullary junction [Figure 1].
Figure 1
Computed tomography scan showing bilateral nephromegaly
The infantile leukemias are rare entity, and they present with a more aggressive clinical
features, are more difficult to treat than leukemia in older children, and have a
poor prognosis. Only 2–5% of ALL cases occur in infants.[1] The common clinical presentations
of leukemia in infants and children include high-grade fever (most common – 50–60%),
anemia, easy fatigability, easy bruising, petechiae, bony pains, and infections. The
most common sites of extramedullary involvement in leukemias are liver, spleen, and
lymph nodes. Kidneys are also sites for extramedullary dissemination of leukemias
with infiltration of kidneys being reported in 7–42% cases of childhood leukemia.
However, presentation with bilateral palpable renal masses at initial presentation
is very rare, more so in infants. The differential diagnosis of bilateral enlarged
kidneys in infants includes polycystic kidney disease, bilateral hydronephrosis due
to distal obstruction (Posterior urethral valve), Wilms tumor (5–10% are bilateral),
infiltration by leukemic cells, storage disorders, and diffuse nephroblastomatosis.
Although leukemias usually have a high total leukocyte count at presentation, cases
of ALL with nephromegaly without raised counts have been documented in children and
adults. Renal infiltration resulting in bilateral nephromegaly is usually found more
commonly in the late stages of the disease. The route of dissemination to kidneys
is hematogenous. Rarely, in about 1% of such cases, the patients may present with
acute kidney injury.[2]
The most common computed tomography finding in renal leukemic involvement is presence
of focal parenchymal abnormalities with multiple bilateral masses. However, a number
of patterns have been recognized which include diffuse bilateral or unilateral involvement,
solitary unilateral or bilateral masses, and ill-defined parenchymal involvement.[3]
The impact of nephromegaly on the prognosis and outcome in leukemic patients is inconclusive.
While a few studies reported the presence of nephromegaly as a poor outcome predictor,[4]
others suggested that kidney size as an independent factor, when adjusted for other
prognostic factors, was not associated with poorer survival.[5]
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Conflicts of interest
There are no conflicts of interest.