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      The preventive role of transurethral antibiotic delivery in a rat model

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          Abstract

          Purpose

          There is currently an emerging need for developing improved approaches for preventing urinary tract infections (UTIs) occurring during diagnostic or interventional procedures of the lower urinary tract. We aimed to establish a rat model to assess the use of transurethral antibiotic administration and to provide evidence that this could be used as a preventive therapy.

          Methods

          Animals received fosfomycin trometamol (FOF) either urethrally or orally prior to the procedure. A third group was generated as treatment controls and did not receive any medication. Urethral dilation was conducted to recapitulate an interventional procedure prior to intravesical Escherichia coli administration in all three groups. Finally, sham-operated animals were introduced as a fourth group which did not receive antibiotics or E. coli. Colony counts of urine and tissue cultures for the identification of E. coli and histopathological examinations of the bladder and prostate were conducted.

          Results

          Evaluation of infection intensities in cultures as well as histopathological examination of the bladder and prostate demonstrated a preventative role of transurethral FOF administration. In terms of efficiency, local administration of FOF was similar to oral administration.

          Conclusions

          These results suggest that transurethral antibiotic administration is a promising alternative for preventing UTIs occurring during diagnostic or interventional procedures of the lower urinary tract.

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          Author and article information

          Journal
          Drug Des Devel Ther
          Drug Des Devel Ther
          Drug Design, Development and Therapy
          Dove Medical Press
          1177-8881
          2012
          17 July 2012
          : 6
          : 187-194
          Affiliations
          [1 ]Department of Urology
          [3 ]Department of Microbiology, Diskapı Yildirim Beyazit Training and Research Hospital, Ministry of Health, Ankara, Turkey
          [4 ]Department of Pathology, Diskapı Yildirim Beyazit Training and Research Hospital, Ministry of Health, Ankara, Turkey
          [2 ]Department of Anatomy, Ankara University Faculty of Veterinary Medicine, Ankara, Turkey
          [5 ]Department of Microbiology, Ankara University Faculty of Veterinary Medicine, Ankara, Turkey
          Author notes
          Correspondence: Hakki Ugur Ozok, Kardelen Mah 2066 sok, Siyasal-2 Sit No 83, Batıkent Yenimahalle, Ankara 06370, Turkey, Tel +905 422 424 660, Fax +903 122 552 086, Email drozok@ 123456gmail.com
          Article
          dddt-6-187
          10.2147/DDDT.S32733
          3414373
          22888219
          © 2012 Ozok et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          Categories
          Original Research

          Pharmacology & Pharmaceutical medicine

          urinary tract, cystitis, fosfomycin, infection, prostatitis

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