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      Effect of Dietary Cholesterol and Fat Levels on Lipid Peroxidation and the Activities of Antioxidant Enzymes in Rats

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          Abstract

          The aim of this study was to investigate the effect of dietary fat levels, with or without cholesterol, on lipid peroxidation and the activities of antioxidant enzymes in rats. Thirty-two Wistar rats aged 4 weeks were divided into 4 groups and fed high (20%; HF) or low (5%; LF) fat, with or without l% cholesterol, for 6 weeks. Cholesterol feeding resulted in significantly higher concentrations of serum cholesterol, but lowered serum triacylglycerol levels. Cholesterol feeding also led to markedly decreased levels of hepatic thiobarbituric acid reactive substances (TBARS) and lower activities of hepatic superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase, and glucose-6-phosphate dehydrogenase (G6PDH) when compared with cholesterol-free counterparts in both HF and LF diets. On the other hand, rats fed high-fat diets showed increased serum and liver TBARS, but decreased hepatic GSH-Px, SOD, and G6PDH activities. Hepatic catalase activity was lower in rats fed cholesterol-containing diets, but higher in rats fed high-fat diets, and interaction existed between cholesterol and fat feeding. These results suggested that dietary cholesterol might delay lipid peroxidation and decrease the activities of the hepatic antioxidant enzymes. The degree of lipid peroxidation was also influenced by dietary fat levels.

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          Author and article information

          Journal
          vit
          122286
          International Journal for Vitamin and Nutrition Research
          Hogrefe AG, Bern
          0300-9831
          1664-2821
          1 November 2001
          14 March 2013
          : 71
          : 6 ( otherID: T3156X11X852 )
          : 339-346
          Affiliations
          [ 1 ] Department of Nutrition and Food Sciences, Fu-Jen University, Taipei 242, Taiwan
          [ 2 ] Department of Nutrition and Food Sciences, Fu-Jen University, Taipei 242, Taiwan
          Article
          X2J501L2887LJ1H8
          10.1024/0300-9831.71.6.339
          11840837
          d54d5e97-8c26-47fa-81c5-2cd4f4e2423d
          History
          Categories
          Original Communication

          Endocrinology & Diabetes,Medicine,Nutrition & Dietetics
          antioxidant enzymes,liver lipids,dietary cholesterol, Fat levels,TBARS,serum lipids

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