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      Neuroeffector Function of Isolated Portal Vein from Spontaneously Hypertensive and Wistar-Kyoto Rats: Dependence on External Calcium Concentration

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          Abstract

          The calcium dependence of the vascular neuroeffector function has been studied in the portal vein of spontaneously hypertensive Okamoto rats (SHR) and Wistar-Kyoto rats (WKY). The noradrenaline (NA) sensitivity of veins of both species, expressed in terms of ED<sub>50</sub>, was decreased to the same extent in relation to the reduction in Ca<sup>2+</sup> ion concentration below 2.5 mM. The responses to individual NA concentrations at subnormal Ca<sup>2+</sup> concentrations were better maintained, however, in portal veins from SHR than from WKY, indicating that the excitation contraction coupling mechanism is less dependent on external Ca<sup>2+</sup> concentrations in the portal vein from SHR than from WKY. In both strains of rats the spontaneous myogenic activity of the vessel was depressed in low Ca<sup>2+</sup> concentrations to a greater extent than responses to nerve stimulation, which, in turn, were more reduced than the excitatory responses to exogenous NA or acetylcholine (ACh). Transmitter release (fractional overflow of <sup>3</sup>H-NA/impulse) was less dependent on Ca<sup>2+</sup> concentrations than the contractile nerve stimulation response. The persistance of all responses in reduced Ca<sup>2+</sup> concentrations was significantly greater in the portal vein of SHR. It is concluded that the phasic, spontaneously active smooth muscle of the rat portal vein is highly dependent on the external calcium concentration and that various induced responses persist to a varying degree in reduced Ca<sup>2+</sup> concentrations. It is suggested that this is due to interference with electromechanical coupling as well as myogenic spread of activation. Induced responses of the portal vein from SHR are, in general, less affected by decreased Ca<sup>2+</sup> concentrations than the WKY portal vein, indicating an altered vascular smooth muscle excitation-contraction coupling mechanism in spontaneous hypertension. Possibly an increased efficiency of the coupling mechanism may contribute to augment vascular responses in the development of hypertension and promote structural vascular changes.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1981
          1981
          19 September 2008
          : 18
          : 3
          : 89-99
          Affiliations
          Department of Physiology, University of Göteborg, Göteborg, and Department of Pharmacology, AB Hassle, Molndal, Sweden; The Alton Ochsner Medical Foundation, New Orleans, La., USA
          Article
          158341 Blood Vessels 1981;18:89–99
          10.1159/000158341
          © 1981 S. Karger AG, Basel

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          Page count
          Pages: 11
          Categories
          Research Paper

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