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      Left-Ventricular Unloading by Transvalvular Axial Flow Pumping in Experimental Cardiogenic Shock and during Regional Myocardial Ischemia

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          Abstract

          The efficacy of the transfemoral left-ventricular assist device Hemopump<sup>TM</sup> (HP; 21 Fr outer diameter) was examined in experiments with adult sheep in two different models of cardiogenic shock (tachycardia shock; ischemia shock), and during ventricular fibrillation. During tachycardia (high frequency pacing-induced; n = 14), HP assist led to a significant increase in cardiac output (from 2.2 to 2.8 liters/min), mean aortic pressure (from 47.6 to 65.6 mm Hg), and myocardial perfusion pressure (from 25.5 to 59.0 mm Hg). Simultaneously, a normalization of body oxygen-uptake (from 1.4 to 2.5 ml/min·kg), a decrease in myocardial oxygen consumption (from 6.1 to 4.8 ml/min·lOO g), and a normalization of myocardial lactate metabolism were ovserved during HP assist. During regional myocardial ischemia (PTCA balloon occlusion of the proximal LAD (3.5 min; n = 12), HP assist led to significant decrease in LV enddiastolic pressure (from 21.1 to 12.1 mm Hg), and increase in diastolic aortic pressure (from 58 to 67 mm Hg) resulting in significant increase in coronary perfusion pressure. In the early reperfusion period, myocardial release of both lactate and potassium was significantly lowered with HP assist. During ventricular fibrillation (induced by electrical stimulation; n = 9), HP flow rates decreased from 2.5 (after 10 min) to 2.1 liters/min (after 30 min). Mean aortic pressures simultaneously decreased from 64.0 to 54.6 mm Hg. Perfusion conditions were sufficient for maintenance of aerobic myocardial metabolism, but were borderline for peripheral circulation. Our hemodynamic and metabolic data demonstrate beneficial effects of cardiac assist with the Hemopump 21 Fr in both tachycardia-induced severe cardiogenic shock and during acute regional myocardial ischemia. During ventricular fibrillation, flow conditions were sufficient to maintain aerobic myocardial metabolism, but circulatory supply to the total organism was borderline.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-5957-7
          978-3-318-01955-1
          0008-6312
          1421-9751
          1994
          1994
          18 November 2008
          : 84
          : 3
          : 202-210
          Affiliations
          Departments of Cardiology and Experimental Cardiology, Georg August University, Göttingen, FRG
          Article
          176399 Cardiology 1994;84:202–210
          10.1159/000176399
          8205570
          © 1994 S. Karger AG, Basel

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          Page count
          Pages: 9
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