Progress of researches on the involvement of indoleamine 2, 3-dioxygenase in regulation of parasite-host immune interactions

Abstract

Indoleamine 2, 3-dioxygenase (IDO) is an important immunoregulatory enzyme, which mediates immune effects by depleting tryptophan and producing multiple metabolites. Recently, the studies on the immune function of IDO have been mostly restricted in tumors and autoimmune diseases. Nevertheless, there are few studies pertaining to the role of IDO in parasitic diseases, notably in parasite-host immune interactions. This review mainly describes IDO-mediated immunoregulatory effects and its regulation of parasite-host interactions, so as to provide insights into the development of immune intervention schemes against parasitic diseases.

Abstract

［摘要］ 吲哚胺2, 3-双加氧酶 (indoleamine 2, 3-dioxygenase, IDO) 是一种重要的免疫调节酶, 主要通过耗竭色氨酸 (tryp-tophan, Trp) 和产生多种代谢产物来调节免疫效应。近年来, 对IDO免疫功能的研究大多局限在肿瘤、自身免疫性疾病等 领域, 而在寄生虫病中的研究相对较少, 尤其是寄生虫与宿主免疫互作关系的研究。本文综述了IDO介导的免疫调节作 用及其与寄生虫-宿主间关系的研究进展, 旨在为抗寄生虫病免疫干预方案的研究提供思路。