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      Ganglioneuroblastoma cervical gigante como causa de trastornos del sueño en niños Translated title: Giant cervical ganglioneuroblastoma as a cause of sleep disorders in children

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          Abstract

          RESUMEN El ganglioneuroblastoma es un tumor derivado de los neuroblastos, generalmente originado a partir de estructuras simpáticas, típicamente localizado en la glándula suprarrenal. En este artículo presentamos un caso excepcional de una paciente de 6 años con un ganglioneuroblastoma cervical que desarrolló trastornos del sueño derivados de la compresión de la vía aérea desde su primer año de vida.

          Translated abstract

          ABSTRACT Ganglioneuroblastoma is a tumor derived from neuroblasts, generally related to sympathetic structures, which is usually located in the adrenal gland. In this article, we present a rare case of a patient with cervical ganglioneuroblastoma, who developed sleep disorders since the first year of life due to compression of the airway.

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          Most cited references8

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          Overview and recent advances in the treatment of neuroblastoma.

          Children with neuroblastoma have widely divergent outcomes, ranging from cure in >90% of patients with low risk disease to <50% for those with high risk disease. Recent research has shed light on the biology of neuroblastoma, allowing for more accurate risk stratification and treatment reduction in many cases, although newer treatment strategies for children with high-risk and relapsed neuroblastoma are needed to improve outcomes. Areas covered: Neuroblastoma epidemiology, diagnosis, risk stratification, and recent advances in treatment of both newly diagnosed and relapsed neuroblastoma. Expert commentary: The identification of newer tumor targets and of novel cell-mediated immunotherapy agents may lead to novel therapeutic approaches, and clinical trials for regimens designed to target individual genetic aberrations in tumors are underway. A combination of therapeutic modalities will likely be required to improve survival and cure rates for patients with high-risk neuroblastoma.
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            The International Neuroblastoma Pathology Classification (the Shimada system)

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              Primary pediatric neuroblastic tumors of the neck.

              Neuroblastic tumors are the third most common cause of solid tumors in early childhood. Cervical tumors account for only 5% of cases. In this report, we describe a series of four pediatric neuroblastic tumors of the neck. The histological diagnosis was ganglioneuroblastoma in three cases and neuroblastoma in one case. Presenting signs were solitary cervical mass in two cases and respiratory distress in association with Claude-Bernard Horner's syndrome in two cases. Mean age at presentation was 15 months. Cervical computed tomography scan and/or magnetic resonance imaging depicted calcifications within the tumor in 50% of cases and allowed accurate assessment of extension. Increased urine catecholamine levels were observed only in the patient with neuroblastoma. Scintigraphy with [131]iodine-methyliodobenzylguanidine demonstrated selective uptake by the tumor in two cases. Amplification of N-myc oncogene, a documented unfavorable prognostic sign, was not found in any case. Surgical treatment was performed in all patients. Neoadjuvant chemotherapy was performed in one case. All patients underwent regular surveillance. No evidence of recurrence has been observed with a mean follow-up period of 7 years.
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                Author and article information

                Journal
                maxi
                Revista Española de Cirugía Oral y Maxilofacial
                Rev Esp Cirug Oral y Maxilofac
                Sociedad Española de Cirugía Oral y Maxilofacial y de Cabeza y Cuello (Madrid, Madrid, Spain )
                1130-0558
                2173-9161
                September 2022
                : 44
                : 3
                : 130-132
                Affiliations
                [3] Valencia orgnameUniversidad de Valencia orgdiv1Departamento de Cirugía España
                [1] Valencia orgnameHospital Clínico Universitario de Valencia orgdiv1Servicio de Cirugía Maxilofacial España
                [2] Valencia orgnameHospital Clínico Universitario de Valencia orgdiv1Servicio de Cirugía Pediátrica España
                Article
                S1130-05582022000300008 S1130-0558(22)04400300008
                10.20986/recom.2022.1401/2022
                d55e4ab1-4950-4804-8a13-eae0b1930894

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

                History
                : 12 October 2022
                : 02 November 2022
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 8, Pages: 3
                Product

                SciELO Spain

                Categories
                Casos Clínicos

                sleep disorders,cervical,tumor,Ganglioneuroblastoma,trastornos del sueño

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