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      Mechanisms of vascular calcification in chronic kidney disease.

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          Abstract

          Vascular calcification is common in chronic kidney disease and associated with increased morbidity and mortality. Its mechanism is multifactorial and incompletely understood. Patients with chronic kidney disease are at risk for vascular calcification because of multiple risk factors that induce vascular smooth muscle cells to change into a chondrocyte or osteoblast-like cell; high total body burden of calcium and phosphorus due to abnormal bone metabolism; low levels of circulating and locally produced inhibitors; impaired renal excretion; and current therapies. Together these factors increase risk and complicate the management of vascular calcification.

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          Author and article information

          Journal
          J Am Soc Nephrol
          Journal of the American Society of Nephrology : JASN
          American Society of Nephrology (ASN)
          1533-3450
          1046-6673
          Feb 2008
          : 19
          : 2
          Affiliations
          [1 ] Department of Medicine, Indiana University, 1001 W. 10th Street, OPW 526, Indianapolis, IN 46202, USA. smoe@iupui.edu
          Article
          ASN.2007080854
          10.1681/ASN.2007080854
          18094365
          d56f203b-9636-4d28-8680-120c506bce09
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