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      Low Serum Bone Gamma-Carboxyglutamic Acid Protein Concentrations in Patients with Cystic Fibrosis: Correlation with Hormonal Parameters and Bone Mineral Density

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          Abstract

          In 31 children and adolescents with cystic fibrosis (CF), whose bone mineral density (BMD) was determined at the level of the lumbar spine, serum bone γ-carboxyglutamine acid (GLA) protein (BGP) was measured. A standard radioimmunoassay method gave for the studied CF population a median serum BGP concentration of 9 µg/l (range: 0.8-18.6) which corresponds to a median Z-score for age of-1.72 (range: -3.3 to +0.04). Thirteen patients presented a BGP concentration lower than 2 standard deviations (SD) under the mean for age. These patients did not differ from the others by their circulating thyroxine, triiodothyronine, 25-hydroxyvitamin D or parathyroid hormone levels. The lowering of the BGP concentration was neither related to the growth velocity nor to the severity of the lung disease, as assessed by lung scintigraphy. Six patients with a decreased BMD ( < 2 SD under mean for age) were found. Five of them had also a decreased BGP concentration. In conclusion, decreased serum BGP concentration was found in 42% of the studied CF patients and could not be related to hormonal abnormalities. Serum BGP had a low specificity (72%) in predicting osteopenia in young CF patients.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1993
          1993
          03 December 2008
          : 39
          : 5-6
          : 197-201
          Affiliations
          Department of Pediatrics, Laboratory of Radioimmunoassay, and Department of Nuclear Medicine, Akademisch Ziekenhuis VUB; Department of Clinical Chemistry, Hôpital Universitaire Brugmann, Free Universities of Brussels, Belgium
          Article
          182735 Horm Res 1993;39:197–201
          10.1159/000182735
          8314203
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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