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Efficacy of extended-release tramadol for treatment of prescription opioid withdrawal: a two-phase randomized controlled trial.

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      Abstract

      Tramadol is an atypical analgesic with monoamine and modest mu opioid agonist activity. The purpose of this study was to evaluate: (1) the efficacy of extended-release (ER) tramadol in treating prescription opioid withdrawal and (2) whether cessation of ER tramadol produces opioid withdrawal.

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      Affiliations
      [1 ] University of Kentucky (UK), Department of Psychiatry, Lexington, KY 40509, USA; UK, Department of Behavioral Science, Lexington, KY 40502, USA; UK, Center on Drug and Alcohol Research, Lexington, KY 40502, USA. Electronic address: michelle.lofwall@uky.edu.
      Journal
      Drug Alcohol Depend
      Drug and alcohol dependence
      Elsevier BV
      1879-0046
      0376-8716
      Nov 01 2013
      : 133
      : 1
      23755929
      S0376-8716(13)00185-3
      10.1016/j.drugalcdep.2013.05.010
      3786049
      NIHMS482600

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