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      Efficacy of extended-release tramadol for treatment of prescription opioid withdrawal: a two-phase randomized controlled trial.

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          Abstract

          Tramadol is an atypical analgesic with monoamine and modest mu opioid agonist activity. The purpose of this study was to evaluate: (1) the efficacy of extended-release (ER) tramadol in treating prescription opioid withdrawal and (2) whether cessation of ER tramadol produces opioid withdrawal.

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          Author and article information

          Journal
          Drug Alcohol Depend
          Drug and alcohol dependence
          Elsevier BV
          1879-0046
          0376-8716
          Nov 01 2013
          : 133
          : 1
          Affiliations
          [1 ] University of Kentucky (UK), Department of Psychiatry, Lexington, KY 40509, USA; UK, Department of Behavioral Science, Lexington, KY 40502, USA; UK, Center on Drug and Alcohol Research, Lexington, KY 40502, USA. Electronic address: michelle.lofwall@uky.edu.
          S0376-8716(13)00185-3 NIHMS482600
          10.1016/j.drugalcdep.2013.05.010
          3786049
          23755929

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