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      Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications

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      Polymers

      MDPI

      implants, drug delivery, design, manufacture

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          Abstract

          The oral route is a popular and convenient means of drug delivery. However, despite its advantages, it also has challenges. Many drugs are not suitable for oral delivery due to: first pass metabolism; less than ideal properties; and side-effects of treatment. Additionally, oral delivery relies heavily on patient compliance. Implantable drug delivery devices are an alternative system that can achieve effective delivery with lower drug concentrations, and as a result, minimise side-effects whilst increasing patient compliance. This article gives an overview of classification of these drug delivery devices; the mechanism of drug release; the materials used for manufacture; the various methods of manufacture; and examples of clinical applications of implantable drug delivery devices.

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          Most cited references 125

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          Biodegradable polymers as biomaterials

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            Synthetic biodegradable polymers as orthopedic devices.

            Polymer scientists, working closely with those in the device and medical fields, have made tremendous advances over the past 30 years in the use of synthetic materials in the body. In this article we will focus on properties of biodegradable polymers which make them ideally suited for orthopedic applications where a permanent implant is not desired. The materials with the greatest history of use are the poly(lactides) and poly(glycolides), and these will be covered in specific detail. The chemistry of the polymers, including synthesis and degradation, the tailoring of properties by proper synthetic controls such as copolymer composition, special requirements for processing and handling, and mechanisms of biodegradation will be covered. An overview of biocompatibility and approved devices of particular interest in orthopedics are also covered.
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              Polymeric systems for controlled drug release.

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                Author and article information

                Journal
                Polymers (Basel)
                Polymers (Basel)
                polymers
                Polymers
                MDPI
                2073-4360
                12 December 2018
                December 2018
                : 10
                : 12
                Affiliations
                School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK; sstewart35@ 123456qub.ac.uk (S.A.S.); j.dominguezrobles@ 123456qub.ac.uk (J.D.-R.); r.donnelly@ 123456qub.ac.uk (R.F.D.)
                Author notes
                [* ]Correspondence: e.larraneta@ 123456qub.ac.uk ; Tel.: +44-(0)28-9097-2360
                Article
                polymers-10-01379
                10.3390/polym10121379
                6401754
                © 2018 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                Categories
                Review

                manufacture, design, drug delivery, implants

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