Interactions between three typical endocrine-disrupting chemicals (EDCs) in binary mixtures exposure on myocardial differentiation of mouse embryonic stem cell
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Abstract
In recent years, various kinds of endocrine-disrupting chemicals (EDCs) have been
detected in human blood and urine. Thus, it was important to investigate the combined
toxicity effect of EDCs. In the present study, we evaluated the individual and combined
developmental toxicities of three classic EDCs: perfluorooctane sulfonate (PFOS),
perfluorooctanoic acid (PFOA), and bisphenol A (BPA) by embryonic stem cell test (EST).
The similarities and differences between combination of same chemical group as well
as different chemical groups were investigated in this research. Our results showed
that the three compounds were all classified as weak embryotoxicity. The results of
co-exposure revealed that there was synergistic action in combination of PFOS and
BPA on myocardial differentiation. However, in all endpoints, the combined effects
between PFOA with PFOS or BPA were both additive action. Therefore, we concluded that
the additive effects were found in most different EDC mixtures whether they had similar
structure or not. On the other hand, synergistic action was observed in a mixture
of EDCs that belonged to a different chemical groups.